TABLE 1

Summary of studies on the impact of rapid molecular detection of respiratory viruses on clinical outcomes and patient management

ReferenceRapid testPatientsDesignComparatorTAT (standard vs rapid [h])Main outcome(s)
Wabe et al. (18)FluA, FluB and RSVHospitalized adultsSame months in consecutive yearsStandard multiplex PCR for 16 viruses27.4 vs 2.3Positive result associated with decrease in LOS; receiving results while in hospital associated with decrease in LOS; decrease in other microbiology tests
Rappo et al. (19)Multiplex PCR for 16 viruses and bacteriaEmergency department and inpatient adults positive for respiratory virusConsecutive influenza seasonsConventional tests and standard multiplex PCR7.7 vs 1.7Influenza positivity associated with lower odds ratios for admission, LOS, duration of antimicrobial use, and no. of chest radiographs
Chu et al. (20)FluA, FluB and RSVHospitalized adultsConsecutive influenza seasonsStandard PCR for FluA, FluB, and RSV25.2 vs 1.7Decrease in duration of oseltamivir use
Rogers et al. (21)Multiplex PCR for 11 virusesHospitalized children >3 monthsSame months in consecutive yearsStandard multiplex PCR for 7 viruses18.7 vs 6.4Higher percentage received result in emergency department; decrease in duration of antibiotic use; positive result associated with decreases in LOS and time in isolation
van Rijn et al. (22)Multiplex PCR for 16 viruses and bacteriaPatients in acute ward, intensive care, and pediatric wardSamples tested by both assays in one seasonStandard multiplex PCR for 18 viruses and bacteria27.1 vs 3.4Decrease in isolation days; oseltamivir started sooner
Andrews et al. (23)Multiplex PCR for 16 viruses and bacteriaInpatients and outpatientsStandard and rapid tests used on alternate days in one seasonStandard multiplex PCR ± atypical serology39.5 vs 19Decrease in time to first dose of antiviral
Brendish et al. (24)Multiplex PCR for 11 viruses and bacteriaEmergency department and inpatient adultsRandomized controlled trial over two winter seasonsStandard PCR for 8 viruses at clinician discretionNAaDecrease in LOS; higher percentage of influenza-positive patients received antiviral; higher percentage received antibiotics for <48 hours
  • a NA, not applicable.