Table 1.

Mutations in rpsL, rrs, and gidB genes in resistant strains

Phenotypic resistanceaMutation found in:No. of strainsSTR MIC (μg/ml)
rpsLrrsgidB
R, H, S
AAG→AGG, K43R8>125
AAG→AGG, K88RGCG→ACG, A183T1125
CTG→TTG, L81L905 A-G117 frameshift (insG350)1125
513 C-T18
513 C-T172
491 C-TGCG→GAG, A200E115
491 C-T18
491 C-T14
TGG→TCG, W45S12
CCG→CTG, P84L12
CAT→TAT, H48Y14
62–8
H, S
513 C-T131
GGT→CGT, G30R115
TGC→TGA, C52stop115
491 C-T18
AAC→ACC, N52T14
S
AAG→AGG, K43R1>125
AAG→AGG, K43R1125
904 C-G1125
GGG→GAG, G117E172
39 frameshift (delC115)18
TTG→TTT, L79F12
CTA→CCA, L49P18
GGC→TGC, G164C18
32–8
Total40
  • a R, rifampin; H, isoniazid; S or STR, streptomycin.