Table 1.

Patient characteristics (n = 152)a

CharacteristicNo. of patients with a CFU/ml of:P valueb
<5 [n = 104 (%)]≥5 [n = 48 (%)]
Age (yr, median)511.5N/A
Age category
    Adult93 (89)17 (35)<0.001
    Pediatric (<18 years)11 (11)31 (65)<0.001
Male sex53 (51)30 (63)0.184
Comorbid disease
    Acute leukemia15 (14)2 (4)0.094*
    Other active malignancy23 (22)6 (13)0.161
    Recent major surgery37 (36)7 (15)0.008
    ESLD (nontransplant)12 (12)00.010*
    Receiving RRT25 (24)4 (8)0.026*
Neutropenia31 (30)5 (10)0.008*
Hematopoietic stem cell transplant8 (8)2 (4)0.506*
Solid organ transplant9 (9)1 (2)0.172*
Receipt of exogenous steroids12 (11)1 (2)0.063*
Receipt of other immune suppressive medication10 (10)8 (17)0.211*
Interrupted GI tract50 (48)13 (27)0.015
Indwelling CVC93 (89)33 (69)0.002
Receiving TPN44 (42)29 (60)0.038
Breakthrough infection10 (9)2 (4)0.341
Patient in ICU63 (61)33 (69)0.332
≤2 Days suspected fungemia63 (61)35 (73)0.140
Candida species<0.001*
    C. albicans63 (61)23 (48)
    C. glabrata16 (15)2 (4)
    C. tropicalis16 (15)6 (13)
    C. parapsilosis4 (4)13 (27)
    Other/mixedc5 (5)4 (8)
Blood culture site0.001
    Peripheral24 (23)23 (48)
    CVC12 (12)9 (19)
    Unknown68 (65)16 (33)
Source of infection0.011
    CVC15 (14)17 (33)
    Extravascular52 (50)14 (29)
    Unknown37 (36)18 (38)
Treatment0.061*
    None17 (16)4 (8)
    Amphotericin B81 (78)35 (73)
    Amphotericin B plus flucytosine5 (5)7 (15)
    Otherd1 (1)2 (4)
Treatment success (n = 130 received antifungal therapy)36 (41)30 (70)0.002
Alive at 30 days46 (44)31 (65)0.020
  • a Abbreviations: GI, gastrointestinal; CVC, central venous catheter; TPN, total parenteral nutrition; ICU, intensive care unit; ESLD, end-stage liver disease; N/A, not applicable; RRT, renal replacement therapy. Boldface data represent statistically significant differences.

  • b P values are 2-tailed via uncorrected chi-square or, when noted, Fisher's exact test (*).

  • c Mixed/other species included mixed cultures (6), C. krusei (1), and C. lusitaniae (2).

  • d Other treatments included fluconazole (n = 2) and cilofungin (n = 1).