Table 3.

Summary of prior studies evaluating organism density in Candida BSI

Study/yrTotal first positive culturesFirst positive only?CFU/ml category rangeNo. (%) of cultures in category rangeComments
Telenti et al. 1991 (20)172Yes<1112 (65)CA-BSI was suspected in 90% and 18% of subjects with CFU/ml values of >2.5 and <1, respectively
1–2.512 (7)
>2.548 (28)
Henry et al. 1983 (7)61Yes<122 (36)
1–1016 (26)
>1023 (38)
Kiehn et al. 1983 (10)91No<143 (47)
1–1027 (30)
11–10014 (15)
>1007 (8)
Kiehn 1989 (9)68No<118 (26)Yeasts, mostly Candida
1–1019 (28)
11–10016 (24)
101–10006 (9)
>10009 (13)
Bille et al. 1984 (3)23Yes<512 (52)Non-albicans Candida spp. and CA-BSI associated with “high-grade” infection; fungal burden not associated with clinical outcome
>511 (48)
  • a Abbreviations: BSI, bloodstream infection; CA-BSI, catheter-associated BSI.