Table 1.

Baseline demographic and clinical characteristicsa

CharacteristicbMSSA strains (n = 58)MRSA strains (n = 43)P valuec
PVLPVL+PVLPVL+
PVL status37/58 (64)21/58 (36)10/43 (23)33/43 (77)0.001
Median age (yr)39.5 (0–77)34 (4–65)68.5 (27–87)29.5 (0.9–87)0.303, 0.012*
Male sex23/37 (62)15/21 (71)3/10 (30)13/33 (39)0.005
Race
    Hispanic17/36 (47)12/18 (67)2/10 (20)10/27 (37)0.074
    African-American14/36 (39)4/18 (22)4/10 (40)13/27 (48)0.725
    Caucasian5/36 (14)2/18 (11)4/10 (40)4/27 (15)0.420
Patient risk factor
    NHR0/37 (0)0/21 (0)3/10 (30)2/33 (6)0.012
    Diabetes11/37 (30)3/21 (14)3/10 (30)6/33 (18)0.704
    ESRD/dialysis3/37 (8)0/21 (0)4/10 (40)1/33 (3)0.280, 0.007*
    HIV3/37 (8)3/21 (14)0/10 (0)2/33 (6)0.461
    Malignancy4/37 (11)0/21 (0)2/10 (20)2/33 (6)0.720
    Device-related infection3/37 (8)2/21 (9)5/10 (50)1/33 (3)0.521, 0.001*
    HA infection in past 6 mo11/36 (31)2/21 (10)9/10 (90)10/33 (30)0.031
    SA infection in past 6 mo1/36 (3)2/21 (9)1/10 (10)8/33 (24)0.027
    Antibiotics in last month8/37 (22)5/21 (24)4/10 (40)9/33 (27)0.374
Presentation of SSTI
    Extremity and buttock20/37 (54)19/21 (43)3/10 (30)14/33 (42)0.400
    Fever of >100.4°F at Dx9/36 (25)2/21 (9)3/10 (30)8/33 (24)0.453
    Median WBC at Dx (range)8.4 (3.2–48)10.9 (6.3–21)9.5 (1.3–24)11.5 (3.7–30.1)0.485
Treatment and outcome
    HA infection23/37 (62)7/21 (33)9/10 (90)18/33 (55)0.267, 0.035*
    Median LOS, days (range)9 (0–134)2 (0–33)11.5 (1–32)4 (0–68)0.442
    Incision and drainage21/37 (57)17/21 (81)7/10 (70)23/33 (70)0.652
    Osteomyelitis4/34 (12)1/21 (5)4/10 (40)2/32 (6)0.526, 0.021*
    Death1/37 (3)0/21 (0)1/10 (10)1/33 (3)0.573
    Appropriate Abx given9/36 (25)3/21 (14)10/10 (100)27/33 (81)0.000
    Median no. of SE (range)6 (2–9)4 (0–8)5 (1–9)3 (0–6)0.002, 0.008*
    SEA+3/37 (8)0/21 (0)0/13 (0)0/33 (0)0.260
    SEB+5/37 (13)0/21 (0)0/10 (0)1/33 (3)0.233
    TSST+5/37 (13)0/21 (0)0/13 (0)0/33 (0)0.070
    mecA IV0/37 (0)0/21 (0)13/13 (100)33/33 (100)0.000
  • a Results are given as numbers (%) of strains with the characteristic, except where indicated.

  • b NHR, nursing home residence; SA, Staphylococcus aureus; Dx, diagnosis; WBC, white blood cells; LOS, length of stay; Abx, antibiotics; SE, staphylococcal enterotoxins.

  • c P values are for MRSA versus MSSA strains, except those marked with an asterisk, which are for PVL+ versus PVL MRSA strains.