Table 2.

Clinical features of three cases with C. auris fungemia

Clinical featureCase 1Case 2Case 3
Age/sexa1 yr/F74 yr/M1 yr 2 months/M
Underlying diseaseHypoxic encephalopathy, aspiration pneumoniaLaryngeal cancerHemophagocytic lymphohistiocytosis
Bloodstream isolate of C. auris
    Date (mo/day/yr) of first isolation12/11/199603/23/200907/27/2009
    No. of positive blood cultures (dateb)3 (51, 54, 60)7 (53, 57, 61, 65, 70, 71, 78)9 (12, 15, 19, 25, 28, 33, 36, 40, 42)
Clinical status at time of positive culture
    Immunosuppressive stateNoNoYes
    Neutropenia (<109/liter)NoNoNo
    Presence of CVCYesYesNo
    Broad-spectrum antibioticsYesYesYes
    Parenteral nutritionYesYesYes
    Surgery within 30 daysNoYesYes
    Intensive careNoYesYes
    Previous antifungal agents within 30 daysYesNoNo
    Concomitant bacteremiaNoNoNo
    Concomitant candidemiaYes (C. albicans)NoYes (C. tropicalis)
    Indwelling urinary catheterNoYesNo
Therapy
    CVC removal (dateb)Yes (61)Yes (71)Not applicable
    Antifungal therapy after cultureYesYesYes
    CVC tip culture result after removalNo growthC. aurisNot applicable
Outcome of fungemiaClearedNot clearedNot cleared
Outcome of patientImprovedExpiredExpired
  • a F, female; M, male.

  • b The numbers indicate the days from the beginning of hospitalization in each patient.