Table 3.

Comparison of FilmArray RP and laboratory-developed PCR assays for pathogens not included in Prodesse assaysa

VirusNo. of specimens with results:Sensitivity (%)Specificity (%)PPV (%)NPV (%)Kappa (95% CI)
LDA/FALDA+/FA+LDA+/FALDA/FA+
Bocavirus17981488.997.866.799.40.75 (0.53-0.97)
Coronavirus 229E18741080.010010099.50.89 (0.66-1)
Coronavirus NL63190011099.5099.5NA
Coronavirus OC4318722150.099.566.798.90.56 (0.07-1)
RV/EV6311801110085.191.51000.88 (0.80-0.95)
  • a In addition, all positive FilmArray RP results for coronavirus HKU1 (n = 1), M. pneumoniae (n = 1), and parainfluenza virus 4 (n = 4) were confirmed by LDAs. Several specimens were tested in blinded fashion by these LDAs, preventing comparison of LDA and FilmArray RP performances for these pathogens. FA, FilmArray RP; PPV, positive predictive value; NPV, negative predictive value; NA, not applicable.