TABLE 1

Performance of nonculture tests for diagnosing deep-seated candidiasisa

TestbMethodStudy groups (n)Sensitivity (%)Specificity (%)Authors, yr (reference)
MannanPlateliaIAC (20) vs at-risk ICU pts (202)4067Leon et al., 2016 (10)
AntimannanPlateliaIAC (20) vs at-risk ICU pts (202)2589Leon et al., 2016 (10)
CAGTAVircellIAC or urologic candidiasis (11) vs at-risk ICU pts and healthy controls (76)7354Fortun et al., 2014 (9)
IAC (20) vs at-risk ICU pts (202)5364Leon et al., 2016 (10)
IAC (18) vs at-risk ICU pts (18)61c80cParra Sanchez et al., 2017 (11)
BDGFungitellIAC (34) vs at-risk ICU pts (73)56d73Nguyen et al., 2012 (22)
IAC (29) vs at-risk ICU pts (60)65e78Tissot et al., 2013 (23)
IAC or urologic candidiasis (11) vs at-risk ICU pts and healthy controls (76)6483Fortun et al., 2014 (9)
IAC (20) vs at-risk ICU pts (202)7757Leon et al., 2016 (10)
PCRCandida real-time PCR panelfIAC (34) vs at-risk ICU pts (73)88d70Nguyen et al., 2012 (22)
Multiplex Candida real-time PCRgIAC or urologic candidiasis (11) vs at-risk ICU pts and healthy controls (76)9197Fortun et al., 2014 (9)
IAC (20) vs at-risk ICU pts (202)86h33hLeon et al., 2016 (10)
  • a Abbreviations: BDG: 1,3-β-d-glucan; IAC, intra-abdominal candidiasis; pts, patients; at-risk ICU pts; patients in an intensive care unit with risk factors for invasive candidiasis.

  • b There are no data for the T2Candida test.

  • c The sensitivity and specificity of the VirClia CAGTA assay were 67% and 76%, respectively.

  • d The sensitivity of blood cultures for IAC was 17%.

  • e The sensitivity of blood cultures for IAC was 6%.

  • f Viracor Eurofins, Lee's Summit, MO. The Candida real-time PCR panel detects C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, and C. krusei. The assay is no longer offered commercially.

  • g Mycology Service of the Spanish National Microbiology Center and Ramon y Cajal Hospital, Madrid, Spain. The Multiplex Candida real-time PCR detects C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii.

  • h PCR was not performed for all patients. Results were positive in 12/14 patients with IAC and negative in 57/85 at-risk critical-care patients and healthy controls.