Table 2

Results of Carba NP test on non-carbapenemase-producing Pseudomonas spp.

Resistance mechanism(s)aOrganismResistance determinant(s)bMIC (mg/liter)Carba NP test result
IMPMER
Wild typeP. aeruginosa 76110None0.750.19
P. aeruginosa PU21None1.50.75
P. aeruginosa ATCC 27853None20.25
P. aeruginosa PAO1None10.5
P. putida CIP 55-5None0.53
AmpC overproductionP. aeruginosa 3-12AmpC30.25
P. aeruginosa VEDAmpC0.120.19
EffluxP. aeruginosa PAO1MexC/D-OprJ>324
P. aeruginosa PT629MexA/B-OprM1.51.5
P. aeruginosa PAO1MexX/Y-OprM1.50.75
Porin deficiencyP. aeruginosa PAO1OprM deficient0.750.5
P. aeruginosa H729OprD deficient>326
P. aeruginosa Paeβ-02OprD deficient44
P. aeruginosa Paeβ-05OprD deficient168
P. aeruginosa Paeβ-30OprD deficient88
P. aeruginosa Paeβ-31OprD deficient168
Porin deficiency and effluxP. aeruginosa Paeβ-19OprD deficient + MexA/B-OprM44
P. aeruginosa Paeβ-29OprD deficient + MexA/B-OprM + MexX/Y-OprM1632
P. aeruginosa Paeβ-01OprD deficient + MexX/Y-OprM + MexC/D-OprJ48
Porin deficiency and AmpC overproductionP. aeruginosa Paeβ-03OprD deficient + AmpC168
P. aeruginosa Paeβ-12OprD deficient + AmpC168
P. aeruginosa Paeβ-13OprD deficient + AmpC168
P. aeruginosa Paeβ-14OprD deficient + AmpC164
P. aeruginosa Paeβ-16OprD deficient + AmpC324
P. aeruginosa Paeβ-23OprD deficient + AmpC3216
P. aeruginosa Paeβ-25OprD deficient + AmpC88
P. aeruginosa Paeβ-26OprD deficient + AmpC44
P. aeruginosa Paeβ-32OprD deficient + AmpC6416
Porin deficiency, AmpC overproduction, and effluxP. aeruginosa Paeβ-04OprD deficient + AmpC + MexA/B-OprM1616
P. aeruginosa Paeβ-24OprD deficient + AmpC + MexA/B-OprM3232
P. aeruginosa Paeβ-28OprD deficient + AmpC + MexA/B-OprM164
P. aeruginosa Paeβ-15OprD deficient + AmpC + MexX/Y-OprM168
P. aeruginosa Paeβ-21OprD deficient + AmpC + MexX/Y-OprM1632
P. aeruginosa Paeβ-22OprD deficient + AmpC + MexC/D-OprJ84
P. aeruginosa Paeβ-06OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-07OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-08OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-09OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-11OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-17OprD deficient + AmpC + MexX/Y-OprM + MexC/D-OprJ328
P. aeruginosa Paeβ-18OprD deficient + AmpC + MexA/B-OprM + MexX/Y-OprM6464
P. aeruginosa Paeβ-27OprD deficient + AmpC + MexA/B-OprM + MexX/Y-OprM3264
P. aeruginosa Paeβ-10OprD deficient + AmpC + MexA/B-OprM + MexC/D-OprJ168
P. aeruginosa Paeβ-20OprD deficient + AmpC + MexA/B-OprM + MexC/D-OprJ168
ESBLP. aeruginosa F6R7GES-110.75
P. aeruginosa DEJGES-921
P. aeruginosa RNL-1PER-166
P. aeruginosa A2O6PER-1133
P. aeruginosa A5O6PER-11.50.38
P. aeruginosa A7O6PER-161
P. aeruginosa A3O6PER-131.5
P. aeruginosa A8O6PER-1>3212
P. aeruginosa A4O6PER-1123
P. aeruginosa E3O6PER-1>3212
P. aeruginosa E1O6PER-10.250.016
P. aeruginosa C2O7PER-1>328
P. aeruginosa C1O7PER-1>32>32
P. aeruginosa 15VEB-121.5
P. aeruginosa 51170BEL-110.5
P. aeruginosa 0602-52025SHV2-a1.53
P. aeruginosa 1782SHV-522
P. aeruginosa SHAMTEM-430.75
P. aeruginosa PU 21OXA-221
P. aeruginosa PAO38OXA-40.0160.19
P. aeruginosa PU 21OXA-1021.5
P. aeruginosa PU 21OXA-1131.5
P. aeruginosa NAJOXA-1321.5
P. aeruginosa PU 21OXA-1422
P. aeruginosa MUSOXA-18 + OXA-20>32>32
P. aeruginosa EDOXA-2820.75
P. aeruginosa PICOXA-31>321.5
P. aeruginosa PG13OXA-32>3212
  • a Lack of OprD, AmpC overexpression, and efflux system overproduction were previously characterized by quantitative reverse transcription-PCR (12).

  • b Bold AmpC corresponds to overexpression of chromosomal AmpC. Mex-type efflux systems are indicated when overexpressed.