Table 5

Comparative detection of coinfections by FilmArray RP and real-time PCR assaysc

Total no. of infectionsDistinct coinfection combination detected by laboratory-developed real-time PCR assaysTotal no. of coinfectionsNo. of discrepant coinfectionsaDiscrepant analyte(s)a
Analyte 1Analyte 2Analyte 3Analyte 4
AdenovirusMPV22Adenovirus (two)
AdenovirusRhinovirus11Adenovirus
AdenovirusIV A H121Adenovirus
AdenovirusIV A H311Adenovirus
AdenovirusPIV type 311Adenovirus
AdenovirusRSV A10
AdenovirusRSV B11Adenovirus
MPVRhinovirus11MPV
MPVIV A 2009 H110
MPVPIV type 111MPV
MPVPIV type 310
MPVM. pneumoniae10
RhinovirusIV A H110
RhinovirusIV A H310
RhinovirusIV A 2009 H130
RhinovirusPIV type 211PIV type 2
RhinovirusPIV type 311PIV type 3
RhinovirusRSV B21RSV B
RhinovirusBocavirus20
RhinovirusB. pertussis60
IV A H1RSV B20
IV A H3IV B11IV B
IV BBocavirus10
PIV type 1Bocavirus10
PIV type 3RSV A10
BocavirusM. pneumoniae10
AdenovirusMPVPIV type 310
AdenovirusMPVRSV B10
RhinovirusPIV type 2RSV B11PIV type 2
RhinovirusPIV type 2Bocavirus10
RhinovirusRSV ABocavirus10
AdenovirusRhinovirusPIV type 3Bocavirus11Adenovirus
Dual381313/76b
Triple511/15b
Quadruple111/4b
Coinfections441515/95
  • a A discrepant coinfection or discrepant analyte was defined as one that was detected by real-time PCR but not detected by the FilmArray Respiratory Panel.

  • b The denominator represents the expected number of detections for specimens containing two (i.e., 38 × 2), three (i.e., 5 × 3), and four (i.e., 1 × 4) pathogens, respectively.

  • c Abbreviations: MPV, metapneumovirus; IV, influenza virus; PIV, parainfluenza virus; RSV, respiratory syncytial virus.