Table 1

Characteristics of patients with invasive aspergillosis

CharacteristicaData [no., no. (%), or median (range)] for:
All patients (n = 57)Patient(s) with IAa defined according to EORTC as:
Proven (n = 4)Probable (n = 44)Possible (n = 9)
Female gender27 (47)1 (25)22 (50)4 (44)
Age (yr)52 (10–78)38 (14–52)52 (10–78)56 (17–64)
Disease
    AML24 (42)1 (25)15 (34)8 (89)
    ALL6 (11)0 (0)5 (11)1 (11)
    CML1 (2)1 (25)0 (0)0 (0)
    Other myeloproliferative disorder1 (2)0 (0)1 (2)0 (0)
    CLL3 (5)0 (0)3 (7)0 (0)
    Malignant lymphoma8 (14)1 (25)7 (16)0 (0)
    MM4 (7)0 (0)4 (9)0 (0)
    AA2 (4)0 (0)2 (5)0 (0)
    Other8 (14)1 (25)7 (16)0 (0)
Phase: 1st CR, 1st chronic phase28 (51)1 (25)24 (57)2 (22)
Autologous HSCT7 (12)1 (25)4 (9)2 (22)
Allogeneic HSCT23 (40)1 (25)20 (45)6 (67)
    If yes, reduced intensity conditioning100100
    If yes, GVHD171151
        Acute grade of ≥2100100
        Extensive chronic6060
Receiving CS31 (54)4 (100)26 (59)1 (11)
    If yes, dose
        <0.5 mg/kg of body wt5 (16)1 (25)4 (15)0 (0)
        0.5–1 mg/kg10 (32)1 (25)8 (31)1 (100)
        1–2 mg/kg14 (45)2 (50)12 (46)0 (0)
        >2 mg/kg2 (6)0 (0)2 (8)0 (0)
Cumulative CS dose the week before diagnosis (mg/kg)2 (0–31)5 (1–7)3 (0–31)0 (0–4)
Received immunosuppressive therapy for <1 month20 (35)2 (50)17 (39)1 (11)
    Mycophenolate mofetil8170
    CsA161141
    ATG2110
    Other8170
Leukocyte count/mm3
    <10027 (47)1 (25)19 (43)7 (78)
    100–50010 (18)2 (50)8 (18)0 (0)
    >50020 (35)1 (25)17 (39)2 (22)
Leucopenia (<500/mm3) for more than 15 days during the last 3 months41 (72)2 (50)30 (68)9 (100)
Antifungal therapy in the last 15 days34 (60)3 (75)26 (59)5 (56)
    As curative therapy2110
    As empirical therapy272205
    Primary prophylaxis4040
    Secondary prophylaxis1010
    Antifungal treatment
        Amphotericin B2 (4)0 (0)2 (5)0 (0)
        Liposomal amphotericin B6 (11)2 (50)4 (9)0 (0)
        Voriconazole3 (5)0 (0)3 (7)0 (0)
        Caspofungin23 (40)1 (25)17 (39)5 (56)
        Other2 (4)0 (0)2 (5)0 (0)
Concomitant pulmonary infection16 (28)2 (50)14 (32)0 (0)
    Bacterial918
    Viral615
    Fungal101
Lung CT scan imaging
    Halo sign33 (58)3 (75)22 (50)8 (89)
    Air crescent sign3 (5)0 (0)3 (7)0 (0)
    Cavity5 (9)0 (0)4 (9)1 (11)
    Other signs34 (60)3 (75)25 (57)6 (67)
  • a AML, acute myeloid leukemia; ALL, acute lymphoid leukemia; CML, chronic myeloid leukemia; CLL, chronic lymphoid leukemia; MM, multiple myeloma; AA, aplastic anemia; CR, complete response; HSCT, hematological stem cell transplantation; GVHD, graft versus host disease; CS, corticosteroids; CsA, cyclosporine; ATG, antithymoglobulin; CT, computed tomography; IA, invasive aspergillosis.