Table 2

Laboratory evaluations at diagnosis

ParameteraNo. of patients with data availableData [no., no. (%), or median (range)] for:
All patients with data availablePatients with:
Proven IAaProbable IAPossible IA
Serum GM antigen57
    Value0.67 (0.02–>10)2.98 (0.67–8.85)0.81 (0.06–>10)0.16 (0.02–0.32)
    Patients with value of ≥0.530 (53)4 (100)26 (59)0 (0)
BAL fluid GM antigen29
    Value1.67 (0–9.80)2.51 (1.00–5.54)1.84 (0.00–9.80)0.17 (0.07–0.24)
    Patients with value of ≥0.518 (62)4 (100)14 (64)0 (0)
Anti-Aspergillus antibodies56
    Value3.2 (0.1–181)2.6 (1.4–20.0)3.7 (0.2–181.0)3.2 (0.1–9.3)
    Patients with value of ≥1210 (18)1 (25)9 (21)0 (0)
Mycological evaluation at diagnosis45
    Positive samples28 (62)3 (100)25 (71)0 (0)
        BA3621 (58)3 (100)18 (69)0 (0)
        BAL fluid3717 (46)3 (100)14 (52)0 (0)
        Sputum2015 (75)1 (100)14 (74)0 (0)
    Species28
        A. fumigatus22 (49)3 (100)19 (54)0 (0)
        A. flavus0 (0)0 (0)0 (0)0 (0)
        A. nidulans2 (4)0 (0)2 (6)0 (0)
        A. niger2 (4)0 (0)2 (6)0 (0)
        Others2 (4)0 (0)2 (6)0 (0)
PCR at diagnosis
    A. fumigatus real-time PCR39
        Positive5 (13)0 (0)4 (14)1 (12)
        Range of positive values (pg of fungal DNA/ml)0.86–12.2
    Aspergillus spp. real-time PCR38
        Positive18 (47)2 (67)10 (37)6 (75)
        Range of positive values (pg of fungal DNA/ml)0.01–340
  • a GM, galactomannan; BAL, bronchoalveolar lavage; BA, bronchial aspirate; IA, invasive aspergillosis.