Table 2

In vitro antifungal susceptibilities of Madurella speciesa

Antifungal agentMIC (μg/ml) for:
M. mycetomatisbM. pseudomycetomatiscM. tropicanaM. fahalii
Amphotericin B1 (<0.03–4)0.5 (0.03)0.1250.5
Ketoconazole0.25 (<0.008–2)0.030.012
Itraconazole0.25 (<0.008–0.5)0.03 (0.06)0.01>16
Posaconazole0.125 (<0.03–0.125)0.010.031
Fluconazole32 (<0.125–>256)128 (>32)4>256
Voriconazole0.5 (<0.008–2)0.06 (0.03)0.031
5-Flucytosine>64>64 (>64)>64>64
Caspofungin>16>16>16>16
  • a One M. fahalii strain, 36 M. mycetomatis strains, 1 M. tropicana strain, and 2 M. pseudomycetomatis strains were tested.

  • b Data are MICs at which 90% of the strains were inhibited (range of MICs).

  • c Data are MICs for M. pseudomycetomatis CBS 216.29, obtained in this study (MICs recorded by Yan et al. [19]).