Table 1

Fluconazole-resistant bloodstream isolates of C. glabrata with decreased susceptibility to one or more echinocandin agent as determined by CLSI broth microdilution methodsa

Isolate no.YrLocationGender/age (yr) of patientMIC (μg/ml)FKS mutationb
ANFCSFMCF
CAS08-00162008GeorgiaM/4710.51S629P(1)
127F2008NAF/492162S629P(1)
CAS11-31122010GeorgiaM/470.50.250.12S629P(1)
CAS11-29782010MarylandF/700.50.50.12S629P(1)
CAS11-31292010MarylandF/704>162S629P(1)
CAS09-14372009GeorgiaF/660.250.250.5R631G(1)
CAS09-16802009GeorgiaF/650.250.51R631G(1)
748F2008WashingtonM/580.250.250.12D632Y(1)
30011F2010NANA0.250.50.03D648E(1)
10956A2006VirginiaF/69120.12F659V(2)
CAS09-08692009MarylandM/39120.25F659Y(2)
CAS08-04252008MarylandF/232164S663P(2)
CAS08-00942008GeorgiaNA4>164S663P(2)
CAS09-17862009GeorgiaNA2>162S663P(2)
CAS09-12252009GeorgiaM/254>164S663P(2)
CAS09-10832009GeorgiaF/510.50.250.12S663F(2)
36670F2010WashingtonNA0.250.250.06NM
53301F2010NANA0.250.120.12NM
CAS10-27322010MarylandM/380.120.250.015NM
  • a M, male; F, female; ANF, anidulafungin; CSF, caspofungin; MCF, micafungin; NA, data not available.

  • b Value in parentheses indicates FKS1 (1) or FKS2 (2); NM, no mutation.