Table 5

Prevalence of virulence traits in relation to source group and ST131 status

Group or virulence factorNo. (%) of isolates with trait by isolate source and ST131 statusP value by isolate source (vs ST131)a
FecalCystitisPyelonephritis
ST131 (n = 4)Non-ST131 (n = 326)ST131 (n = 42)Non-ST131 (n = 280)ST131 (n = 89)Non-ST131 (n = 212)FecalCystitisPyelonephritis
Groups
    A0 (0)130 (40)0 (0)28 (10)0 (0)13 (6)NS0.035NS
    B10 (0)29 (9)0 (0)17 (6)0 (0)13 (6)NS0.0070.012
    B24 (100)98 (30)42 (100)174 (62)89 (100)138 (65)<0.001<0.001<0.001
    D0 (0)68 (21)0 (0)62 (22)0 (0)49 (23)NS<0.001<0.001
Virulence factorsb
    afa/draBC1 (25)19 (6)6 (14)39 (14)19 (21)19 (9)NSNS0.007
    bmaE0 (0)0 (0)2 (5)1 (<1)6 (7)0 (0)NSNS<0.001
    sfaS4 (100)19 (6)9 (21)75 (27)17 (19)48 (22)<0.001NSNS
    fimH4 (100)286 (88)42 (100)275 (98)89 (100)206 (97)NSNSNS
    focG3 (75)30 (9)19 (45)142 (51)35 (39)119 (56)0.003NS0.008
    papGI0 (0)0 (0)1 (2)1 (<1)5 (6)4 (2)NSNSNS
    papGII1 (25)6 (2)16 (38)76 (27)36 (40)84 (40)<0.001NSNS
    papGIII1 (25)16 (5)15 (36)106 (38)35 (39)33 (37)NSNSNS
    papAH4 (100)65 (20)24 (48)169 (60)52 (58)136 (64)0.002NSNS
    papC4 (100)125 (38)18 (43)155 (55)46 (52)129 (61)0.023NSNS
    papEF4 (100)112 (34)21 (50)184 (66)50 (56)142 (67)0.015NSNS
    gafD0 (0)0 (0)3 (7)6 (2)9 (10)9 (4)NSNSNS
    cnf11 (25)62 (19)15 (36)117 (42)37 (42)114 (53)NSNSNS
    hlyA1 (25)91 (28)16 (38)135 (48)34 (40)126 (59)NSNS0.001
    iutA4 (100)52 (16)42 (100)174 (62)89 (100)145 (68)<0.001<0.001<0.001
    fyuA4 (100)98 (30)37 (88)234 (84)76 (85)168 (79)0.009NSNS
    iroN2 (50)84 (26)35 (83)152 (54)78 (88)136 (64)NS<0.001<0.001
    kpsMTII1 (25)75 (23)25 (59)188 (67)54 (61)151 (71)NSNSNS
    kpsMTIII0 (0)3 (1)3 (7)26 (9)4 (5)17 (8)NSNSNS
    traT4 (100)138 (42)42 (100)206 (74)89 (100)137 (65)0.034<0.001<0.001
    ompT4 (100)108 (33)42 (100)161 (58)89 (100)155 (73)0.013<0.001<0.001
    usp4 (100)227 (70)42 (100)125 (45)89 (100)167 (79)0.002<0.001<0.001
Virulence score (median [range])6 (7–12)2 (0–12)8 (8–16)6 (1–13)9 (10–17)7 (1–17)<0.001<0.001<0.001
  • a P values are shown where P < 0.05, calculated by Fisher's exact test, except for last row, where Mann-Whitney U test was used. NS, nonsignificant.

  • b The 22 virulence factors analyzed were afa/draBC, Dr-binding adhesins; bmaE, M fimbriae; sfaS, S fimbriae; fimH, type 1 fimbriae; focG, F1C fimbriae; papG, P fimbria adhesin (and alleles I, II, and III); papA, P fimbria structural subunit; papC, P fimbria assembly; papEF, fimbria tip pilins; gafD, G fimbriae; cnf1, cytotoxic necrotizing factor type1; hlyA, hemolysin; iutA, aerobactin receptor; fyuA, ferric yersiniabactin receptor; iroN, salmochelin receptor; kpsMTII group 2 capsule (with K1 and K2 variants); kpsMTIII, group 3 capsule; traT, serum resistance associated; ompT, outer membrane protein T (protease); usp, uropathogenic specific protein.