Table 1

Characteristics of 135 study patients with aseptic failure and prosthetic joint infectiona

ParameterAseptic failure (n = 100)Prosthetic joint infection (n = 35)P value
Median patient age in yr (range)73 (27–89)73 (48–87)0.878
Male patients36 (36)15 (43)0.545
Type of joint prosthesis
    Knee (n = 73)60 (60)25 (71)0.310
    Hip (n = 31)36 (36)5 (14)0.019
    Shoulder (n = 4)2 (2)3 (9)0.110
    Elbow (n = 4)2 (2)2 (6)0.276
Type of revision surgery
    Debridement and prosthesis retentionb014 (40)<0.001
    One-stage exchange98 (98)1 (3)<0.001
    Two-stage exchangec2 (2)20 (57)<0.001
Clinical signs of infection
    Sinus tract07 (20)<0.001
    Visible pus surrounding the prosthesis025 (71)<0.001
Mean synovial fluid cell countd
    Leukocyte count in g/liter (range)0.3 (0.06–0.8)45 (1.4–76)0.005
    % neutrophils (range)19 (2–44)90 (54–98)0.017
Received previous antibiotics023 (66)<0.001
  • a Values represent numbers (%) where not indicated otherwise. ND, not determined. Boldface P values represent significant values.

  • b The polyethylene inlay and removable metal parts (i.e., femur head), where applicable, were investigated by a vortexing or sonication procedure.

  • c The mean interval between explantation and reimplantation of the prosthesis was 118 days (range, 19 to 357 days).

  • d Synovial fluid was available for 15 patients (11%).