Table 4

Comparison of microbiologic tests for diagnosis of PJI

TestNo. of patients with positive specimens and:Sensitivity (95% CI)Specificity (95% CI)Positive predictive value (95% CI)Negative predictive value (95% CI)
Aseptic failure (n = 290)PJI (n = 144)
Synovial fluid culturea5/16159/8966.3 (55.5–76.0)96.9 (92.9–99.0)92.2 (82.7–97.4)83.9 (77.8–88.8)
Tissue culture
    Any growth4511982.6 (75.4–88.4)84.5 (79.8–88.5)72.6 (65.1–79.2)90.7 (86.6–93.9)
    ≥2 positive tissues (same organism)610170.1 (62.0–77.5)97.9 (95.6–99.2)94.4 (88.2–97.9)86.9 (82.7–90.3)
Sonicate fluid culture510572.9 (64.9–80.0)98.3 (96.0–99.4)95.5 (89.7–98.5)88.0 (83.9–91.3)
Sonicate fluid PCR (10-assay panel)
    Any positive result611177.1 (69.3–83.7)97.9 (95.6–99.2)94.9 (89.2–98.1)89.6 (85.7–92.7)
    Staphylococcus species275
        S. aureus028
        Coagulase-negative staphylococci247
    Streptococcus species311
    Enterococcus/Granulicatella/Abiotrophia species011
    Enterobacteriaceae18
    Gram-positive anaerobic cocci08
    Propionibacterium species08
    P. aeruginosa05
    Corynebacterium species04
        C. jeikeium/C. urealyticum00
        Non-C. jeikeium species04
    Proteus species01
    B. fragilis group00
  • a Denominators are smaller for synovial fluid cultures because samples from fewer patients were submitted for this test.