Table 3

Comparison of in vitro susceptibilities of three echinocandins versus isolates of Candida collected during two different time periodsa

Candida speciesAntifungal agentbYearscNo. of isolates tested% of isolates at an MIC (μg/ml) of:
≤0.0080.0150.030.060.120.250.5124≥8
C. albicansANF2003-20074,2837.929.836.020.95.00.3<0.1
2010-20111,4059.322.635.424.77.00.50.4
CSF2003-20074,2832.127.647.621.01.60.1
2010-20111,4050.716.245.725.910.00.90.40.10.1
MCF2003-20074,28314.268.914.62.10.1
2010-20111,4054.240.247.66.31.10.20.30.1
C. glabrataANF2003-20071,2360.613.057.825.92.10.20.20.20.1
2010-20115710.715.252.025.74.60.41.10.20.2
CSF2003-20071,23610.759.126.62.10.60.60.10.2
2010-20115711.258.523.313.02.50.50.70.20.2
MCF2003-20071,23616.875.65.71.00.30.20.10.20.1
2010-20115719.868.517.52.10.90.20.70.20.2
C. parapsilosisANF2003-20071,2380.10.20.10.11.14.025.861.86.90.1
2010-20115650.20.54.210.132.039.313.10.5
CSF2003-20071,2380.20.42.510.244.032.29.11.30.10.2
2010-20115650.41.410.452.426.28.80.4
MCF2003-20071,2380.20.20.10.85.321.154.617.80.2
2010-20115650.20.92.513.552.929.60.5
C. tropicalisANF2003-20079964.125.549.517.42.40.70.10.3
2010-201131811.937.138.710.71.30.3
CSF2003-20079961.731.948.416.21.20.40.10.1
2010-20113180.618.957.917.04.70.9
MCF2003-20079964.640.237.715.01.70.60.10.2
2010-20113182.227.750.317.31.90.6
C. kruseiANF2003-20072701.558.933.75.20.40.4
2010-2011791.37.631.645.612.71.3
CSF2003-20072700.451.929.314.83.00.70.4
2010-2011791.32.530.421.539.212.9
MCF2003-20072701.510.478.17.82.2
2010-2011791.31.327.868.41.3
  • a All isolates were tested using CLSI broth microdilution methods (17).

  • b ANF, anidulafungin; MCF, micafungin; CSF, caspofungin.

  • c Data from the 2003-2007 period were compiled from the work of Pfaller et al. (36).