Table 4

Summary of fks alterations detected in echinocandin-resistant Candida sp. strains

OrganismState or countryYearMIC (μg/ml) for each indicated antifungal:1,3-β-d-Glucan synthase alterations ina:
AnidulafunginCaspofunginMicafunginfks1 HS1fks1 HS2fks2 HS1bfks2 HS2b
Candida glabrataIndiana2010140.06WTWTF641VWT
C. glabrataBelgium2010110.06WTWTWTWT
C. glabrataMichigan20100.250.50.03WTWTD648EWT
C. glabrataTexas20100.50.250.03WTWTF641YWT
C. glabrataGermany201010.50.5WTWTL644WWT
C. glabrataNew York20100.250.250.5WTWTWTWT
Candida parapsilosisNew York2010821WTWTNTNT
C. parapsilosisNew York2010811WTWTNTNT
C. parapsilosisArgentina2010811WTWTNTNT
Candida albicansSweden20110.511S654PWTNTNT
C. albicansScotland20110.521S629PWTNTNT
C. albicansChina20110.2510.5S645PWTNTNT
C. glabrataAustralia20110.50.250.12F625SWTWTWT
C. glabrataCanada2011110.25WTWTS659YWT
C. glabrataIndiana201110.50.5WTWTS663YWT
C. glabrataAustralia2011110.5WTWTS663PWT
C. glabrataGreece2011211WTWTS663PWT
C. glabrataLouisiana20114162S629PWTWTWT
  • a WT, wild-type.

  • b NT, not tested.