Table 5

Frequency of decreased susceptibility of Aspergillus fumigatus to azole antifungal agents by geographic region using CLSI epidemiological cutoff values

Antifungal agentECVb (μg/ml)No. of isolatesa (% non-wild-type to each antifungal agent) by region
North AmericaEuropeLatin AmericaAsia-PacificTotal
Itraconazole145 (4.4)34 (0.0)13 (0.0)4 (0.0)96 (2.0)
Posaconazole0.545 (15.6)34 (2.9)13 (7.7)4 (0.0)96 (9.4)
Voriconazole145 (2.2)34 (0.0)13 (0.0)4 (0.0)96 (1.0)
  • a All isolates tested using CLSI broth microdilution methods (19).

  • b ECVs as published by Espinel-Ingroff et al. (37).