Table 2

MIC distributions for isavuconazole and six comparator antifungal agents tested against Candida spp. using CLSI broth microdilution methods

Species (n)Antifungal agentaNo. of isolates with an MIC (μg/ml) of:
≤0.0080.0150.030.060.120.250.51248163264128
C. albicans (578)ISA22231240211
PSC10952861632121
VRC51951611
FLC2035118712611
ANF701701881232313
CSF5131342897211
MCF5437614422
C. glabrata (266)ISA3112457915012108
PSC117261198511214
VRC153494822061095
FLC232557112366520
ANF134166584111
CSF41866011311
MCF43201172111
C. parapsilosis (262)ISA9551077011442
PSC3451515481
VRC851431710421
FLC45315828122221
ANF114226713730
CSF1627153669
MCF1463916646
C. tropicalis (130)ISA1104247194421
PSC1546571362
VRC144149811411
FLC176035564111
ANF1441561342
CSF226772032
MCF43765231
C. krusei (45)ISA2312199
PSC214254
VRC82971
FLC112761
ANF16245
CSF161217
MCF11529
C. lusitaniae (28)ISA91252
PSC631441
VRC1882
FLC1412632
ANF11171431
CSF1126153
MCF3461131
C. dubliniensis (22)ISA8941
PSC18112
VRC1921
FLC71041
ANF16861
CSF7132
MCF13135
C. kefyr (11)ISA281
PSC1253
VRC74
FLC164
ANF251111
CSF2621
MCF62111
C. guilliermondii (8)ISA3311
PSC332
VRC611
FLC5111
ANF1151
CSF2114
MCF12131
C. fermentati (5)ISA221
PSC122
VRC311
FLC32
ANF311
CSF131
MCF32
C. intermedia/pseudointermedia (3)ISA21
PSC21
VRC21
FLC21
ANF12
CSF3
MCF21
  • a ISA, isavuconazole; PSC, posaconazole; VRC, voriconazole; FLC, fluconazole; ANF, anidulafungin; CSF, caspofungin; MCF, micafungin.