Table 4

MIC distributions for isavuconazole and comparator antifungal agents tested against non-Candida yeasts and non-Aspergillus molds using CLSI broth microdilution methods

Species (n)Antifungal agentaNo. of isolates with an MIC/MEC (μg/ml) of:
≤0.0080.0150.030.060.120.250.51248163264128
Cryptococcus neoformans (46)ISA421174
PSC4172221
VRC21317131
FLC131316112
ANF145
CSF13312
MCF46
Trichosporon spp. (8)bISA21221
PSC2132
VRC2411
FLC125
ANF17
CSF35
MCF8
Penicillium spp. (8)cISA111212
ITR1421
PSC1421
VRC5111
ANF21221
CSF31211
MCF1221
Paecilomyces spp. (4)dISA31
PCS112
VRC121
ANF112
CSF112
MCF112
Gibberella fujikuroi SC (3)ISA111
PSC111
VRC111
ANF12
CSF12
MCF3
Sarocladium spp. (3)eISA111
PSC21
VRC111
ANF111
CSF21
MCF111
Scedosporium apiospermum (3)ISA12
PSC111
VRC12
ANF111
CSF111
MCF21
  • a ISA, isavuconazole; ITR, itraconazole; PSC, posaconazole; VRC, voriconazole; FLC, fluconazole; ANF, anidulafungin; CSF, caspofungin; MCF, micafungin.

  • b Includes T. asahii (three isolates), T. ovoides (one isolate), and Trichosporon not identified at the species level (four isolates).

  • c Includes Penicillium subgenus Aspergilloides (three isolates) and one isolate each of Penicillium citrinum, Penicillium roqueforti, Penicillium subgenus Furcatum, Penicillium subgenus Terverticillata, and Penicillium not identified at the species level.

  • d Includes Paecilomyces lilacinus (three isolates) and Paecilomyces variotii (one isolate).

  • e Includes Sarocladium kiliense (two isolates) and Sarocladium bacillisporum (one isolate).