Table 1

Demographic and baseline clinical characteristics of samples used in this study

CharacteristicsHC (n = 40)aCDI (n = 39)CDN (n = 36)
Age (yr [mean ± SD])b60.9 ± 9.154.7 ± 20.154.6 ± 20.0
Female (n [%])28 (70)16 (41)19 (53)
Caucasian (n [%])b27 (68)28 (72)24 (67)
Previous episode of CDI (n [%])09 (23.1)5 (13.9)
Disease severity (n [%])c
    Mild or moderateNA27 (69.2)31 (86.1)
    SevereNA8 (20.5)5 (13.9)
    Severe-complicatedNA4 (10.3)0
White blood cell count (mean ± SD]) (cells/μl)dNA11.9 ± 7.68.7 ± 5.4
Received antibiotics within 3 mo (n [%])9 (22.5)34 (87.2)21 (58.3)
Concomitant systemic antibiotic therapy (n [%])017 (43.6)15 (41.7)
Treatment for CDI in previous 24 h (n [%])NA5 (12.8)NA
  • a HC, healthy control; CDI, C. difficile infection; CDN, C. difficile negative nosocomial diarrhea; NA, not applicable or data not available.

  • b There were no significant between-group differences.

  • c Disease severity was defined according to reference 43; mild or moderate, white blood cell count of <15,000 cells/μl and serum creatinine level <1.5 times the premorbid level; severe, white blood cell count of ≥15,000 cells/μl or serum creatinine level ≥1.5 times the premorbid level; severe-complicated, hypotension or shock, ileus, or megacolon.

  • d P = 0.47, CDI group versus CDN group.