TABLE 2

Sensitivities, specificities, and predictive values of the CAP/CTM with DBS or DPS for diagnosing ARV TFa,b

Specimen typeNo. of plasma DBS or DPS pairsDiagnostic threshold, copies/mlSensitivity (CI)Specificity (CI)PPV (CI)NPV (CI)
DBS823>5,0000.99 (0.96–1.00)0.55 (0.51–0.59)0.33 (0.29–0.37)1.00 (0.98–1.00)
>1,0000.99 (0.97–1.00)0.26 (0.22–0.29)0.29 (0.26–0.33)0.99 (0.96–1.00)
DPS546>5,0000.88 (0.81–0.94)0.98 (0.96–0.99)0.92 (0.85–0.97)0.97 (0.95–0.98)
>1,0000.91 (0.85–0.95)0.96 (0.94–0.98)0.89 (0.83–0.94)0.97 (0.94–0.98)
  • a Plasma VL is the reference standard for sensitivity, specificity, and predictive values of VL in DBS or DPS. Plasma, DBS, or DPS that had a VL that was undetectable or lower than the LOD were classified as negative (i.e., <5,000 copies/ml or <1,000 copies/ml) for ARV TF.

  • b All confidence intervals (CIs) are reported at the 95% confidence level.