TABLE 1

Panel of genes associated with mobile genetic elements used for BLAST querya

Antimicrobial agent(s)GenebProductcReference gene accession no. (nucleotide positions)
PenicillinblaZClass A beta-lactamaseBX571856.1 (1913827–1914672)
MethicillinmecALow-affinity PBP2BX571856.1 (44919–46925)
ErythromycinmsrA*Erythromycin resistance proteinCP003194 (54168–55634)
Erythromycin and clindamycinermArRNA adenine N-6-methyltransferaseBA000018.3 (56002–56733)
ermBrRNA adenine N-6-methyltransferaseAB699882.1 (4971–5708)
ermCrRNA adenine N-6-methyltransferaseHE579068 (7858–8592)
ermT23S rRNA methylaseHF583292 (11344–12078)
TetracyclinetetKMFS tetracycline effux pumpFN433596 (69118–70497)
tetLMFS tetracycline efflux pumpHF583292 (7713–9089)
tetMRibosomal protection proteinCP002643 (427033–428952)
VancomycinvanALow-affinity peptidoglycan precursorAE017171.1
Fusidic acidfusBFusidic acid detoxificationCP003193.1 (1336–1977)
far*Ribosome protection proteinAY373761.1 (19072–19713)
TrimethoprimdfrAInsensitive dihydrofolate reductaseCP002120 (2093303–2093788)
dfrGInsensitive dihydrofolate reductaseFN433596 (502263–502760)
GentamicinaacA-aphD6′-aminoglycoside N-acetyltransferase/2″-aminoglycoside phosphotransferaseFN433596.1 (2209531–2210970)
Mupirocin (high-level resistance)mupAIsoleucyl-tRNA synthetaseHE579068 (2157–5231)
mupBIsoleucyl-tRNA synthetaseJQ231224
  • a Presence of the gene correlates with phenotypic resistance. Reference sequences were obtained from published sequences from human clinical isolates.

  • b An asterisk indicates that the gene was added in v2.0.

  • c MFS, major facilitator superfamily.