TABLE 1

Baseline characteristics of the study population

ParameterValue for population analysis groupa
Overall (n = 200)cSAB infection sourceOutcome
Hemodialysis (n = 100)Postsurgical (n = 100)P valuebFailure (n = 60)Cured (n = 133)P valueb
Sex
    Male89 (44.5)45 (45)44 (44)1.0023 (38.3)64 (48.1)0.22
    Female111 (55.5)55 (55)56 (56)37 (61.7)69 (51.9)
Race
    White96 (49.0)23 (23.2)73 (75.3)<0.000135 (59.3)59 (45.4)0.086
    African-American100 (51.0)76 (76.8)24 (24.7)24 (40.7)71 (54.6)
Age (yrs)58 [18, 84]55 [23, 84]60 [18, 83]0.0663 [26, 84]55 [19, 83]0.009
Route of acquisition
    Hospital60 (30.3)9 (9.0)51 (52.0)<0.000122 (37.3)36 (27.3)0.18
    Community129 (65.2)85 (85.0)44 (44.9)33 (55.9)91 (68.9)
    Nursing home9 (4.5)6 (6.0)3 (3.1)4 (6.8)5 (3.8)
APACHE II score14 [1, 27]16 [8, 27]13 [1, 26]<0.000116 [1, 26]14 [3, 27]0.001
Reported duration of symptoms (days)2 [0,30]2 [1, 26]1 [0, 30]0.612 [0, 26]1 [1, 30]0.71
Persistent fever at 72 h113 (65.3)70 (78.7)43 (51.2)0.000225 (49.0)82 (70.7)0.009
Methicillin-resistant S. aureus116 (58)57 (57)59 (59)0.8944 (73.3)68 (51.1)0.004
Metastatic diseased
    Any62 (31.2)41 (41.0)21 (21.2)0.00424 (40.0)36 (27.3)0.09
    Osteoarticular23 (11.6)14 (14)9 (9.1)0.3812 (20.0)11 (8.3)0.03
    Endocarditis26 (15.0)20 (22)6 (7.3)0.01012 (21.4)14 (12.6)0.17
    Others34 (17.1)24 (24)10 (10.1)0.01410 (16.7)22 (16.7)1.00
Positive blood culture on follow-upe76 (47.5)55 (59.8)21 (30.9)0.000424 (52.2)49 (44.1)0.38
Alpha-toxin ELISA negative27 (13.5)11 (11.0)16 (16.0)0.422212 (20.0)15 (11.3)0.0482
Alphta-toxin ELISA positive173 (86.5)89 (89.0)84 (84.0)48 (80.0)118 (88.7)
Anti-alpha-toxin-neutralizing antibody seronegative156 (78.0)77 (77.0)79 (79.0)0.864648 (80.0)104 (78.2)0.8508
Anti-alpha-toxin-neutralizing antibody seropositive44 (22.0)23 (23.0)21 (21.0)12 (20.0)29 (21.8)
  • a Data are reported as the number (with the percentage of the total in parentheses) for categorical variables; continuous variables are reported as means [with the minimimum and maximum values in brackets].

  • b P values were calculated using Fisher's exact test for categorical variables and the Kruskal-Wallis test for continuous variables.

  • c Not all patient-related information was available for all subjects.

  • d The total number of study subjects with metastatic disease is less than the sum for the specific metastatic sites because some patients had >1 metastatic infection sites.

  • e Follow-up blood cultures were not available for all study subjects.