TABLE 3

hla genotypes associated with S. aureus bacteremia among hemodialysis and postsurgery patients

hla genotypenAmino acid residue or codon found at positiona:Neutralized by MEDI4893
V6I40L78Q113T155D234S265D272H285T294I301S304K314
1 (USA300)32VILQTDSDHTISKYes
2114ETYes
321IStopSETTNTb
411TYes
57ISTTYes
64EYes
73FTYes
81AISETNTYes
91ISTNTYes
101ISTTCYes
111ISYTYes
121ETNYes
Total197c133221321413111116111
  • a The amino acid numbering system employed starts at the first methionine and includes the whole open reading frame.

  • b NT, not tested. Isolates with a stop codon at Q113 did not produce alpha-toxin and were not tested in the toxin neutralization assay.

  • c Of the 200 isolates, 197 had a detectable hla gene.