TABLE 4

Antibiotic susceptibility testing of maternal nasopharyngeal Streptococcus pneumoniae isolates collected at delivery following a single course of SP and chloroquine or IPTp with sulfadoxine-pyrimethamine (SP) and azithromycin (AZ)f

AntibioticSPCQ (n = 91)SPAZ (n = 30)Pe
No. of isolates (% of total tested)Median MIC, μg/ml (IQR)No. of isolates (% of total tested)Median MIC, μg/ml (IQR)
SIRSIR
Azithromycin89 (97.8)02 (2.2)12b26 (86.7)04 (6.7)70 (7.5, 192)0.033
Ceftriaxone88 (96.7)2 (2.2)d1 (1.1)d30 (100.0)000.422
Chloramphenicol90 (98.9)1 (1.1)0230 (100.0)000.752
Co-trimoxazole52 (57.1)5 (5.4)34 (37.4)6 (1.25, 12)b18 (60.0)012 (40.0)4 (2.5–7)0.783
Penicillina35 (38.5)11 (12.1)45 (49.5)0.25 (0.125, 0.5)b14 (46.7)3 (10.0)13 (43.3)0.25 (0.125, 0.38)0.427
Tetracycline84 (92.3)1 (1.1)6 (6.6)24 (8.125, 40)c26 (86.7)3 (10.0)1 (3.3)32 (24, 32)0.427
MDR(2)54 (59.3)40 (44.0)18 (60.0)12 (40.0)0.949
MDR(3)89 (97.8)2 (2.2)26 (86.7)4 (13.3)0.033
  • a Kirby-Bauer disk diffusion with oxacillin, Etest with penicillin.

  • b Missing MIC data for one isolate.

  • c Missing MIC data for 2 isolates.

  • d All isolates showed reduced sensitivity to oxacillin by disk diffusion; one isolate had a penicillin MIC of 0.047 μg/ml.

  • e P values of <0.05 are marked in bold.

  • f Abbreviations: S, sensitive; I, intermediate; R, resistant; IQR, interquartile range; MDR(2), multidrug resistant—reduced sensitivity to ≥2 antibiotic classes tested by disk diffusion; MDR(3), multidrug resistant—reduced sensitivity to ≥3 antibiotic classes tested by disk diffusion.