TABLE 1

In vitro antifungal susceptibility profile of C. auris, C. haemulonii, and C. duobushaemulonii strains by the CLSI M27-A3 broth microdilution method

Species testedMIC parameterMIC (μg/ml)a
AMBITCVRCISAPOSFLU5-FCCASMFGAFG
C. auris (n = 90 isolates)GM0.80.151.010.180.06360.50.580.110.23
MIC5010.12510.250.06640.250.50.1250.125
MIC9040.582264810.250.5
MIC range0.125–8<0.03–2<0.03–16<0.015–4<0.015–84–>64<0.125– >640.125–8<0.015–8<0.015–8
C. haemulonii (n = 7 isolates)GM12.70.3140.310.0270.05322.820.190.280.44
MIC50160.250.50.0150.12564320.250.250.5
MIC90160.520.250.256464111
MIC range4–160.25–0.5<0.03–4<0.015–0.50.015–0.252–>640.125–>640.06–10.125–10.25–1
C. duobushaemulonii (n = 5 isolates)GM160.3150.0680.0230.116.350.1250.140.350.56
MIC50160.250.060.0150.12580.1250.1250.50.5
MIC90160.50.1250.060.25160.1250.2511
MIC range>160.25–0.5<0.03–0.125<0.015–0.060.03–0.1251–16<0.1250.06–0.250.125–10.5–1
  • a AMB, amphotericin B; ITC, itraconazole; VRC, voriconazole; ISA, isavuconazole; POS, posaconazole; FLU, fluconazole; 5-FC, 5-flucytosine; CAS, caspofungin; MFG, micafungin; AFG, anidulafungin.