Performance characteristics of leukocyte esterase, nitrite, and pyuria tests for detection of significant bacteriuriaa

Result(s) (no. of patients)Sensitivity (%)Specificity (%)PPV (%)NPV (%)LR+bLRc
LEd positive (187)783443701.20.6
Nitrite positive (50)228772421.70.90
Pyuria positivee (186)863146771.20.4
LE and nitrite positive (32)199262642.60.9
LE or nitrite positive, pyuria negative (202)673441341.00.98
LE, nitrite, or pyuria positive (243)951041761.10.5
  • a One or two uropathogens at a growth level of >103 CFU/ml.

  • b LR+, positive likelihood ratio.

  • c LR, negative likelihood ratio.

  • d LE, leukocyte esterase.

  • e Five or more white blood cells per high-power field.