TABLE 1

Summary of 7H9 broth microdilution MIC QC ranges against M. tuberculosis H37Rv strain for anti-TB drugs

DrugDilution range used in the study (μg/ml)MIC QC range (μg/ml)
First-line drugs
    Isoniazida0.03–10.03–0.12
    Rifampin0.06–10.03–0.25
    Ethambutol0.25–80.25–2
    Nicotinamideb16–512NAe
Fluoroquinolones
    Levofloxacin0.12–40.12–1
    Moxifloxacin0.06–20.06–0.5
    Ofloxacin0.12–40.25–2
Second-line injectables
    Amikacin0.12–80.25–2
    Kanamycinc0.12–80.25–2
    Capreomycin0.12–40.5–4
Oral bacteriostatic drugs
    Prothionamide0.06–2NA
    Ethionamide0.12–4NA
WHO category 5 drugs
    Linezolid0.12–40.25–2
    Clofazimined0.06–10.03–0.25
  • a QC range derived from microtiter plate Lot-1 and Lot-2 only.

  • b Nicotinamide was included as a potential surrogate for pyrazinamide.

  • c QC range derived from Lot-2 and Lot-3 only.

  • d The modal concentration of clofazimine, 0.06 μg/ml, was the lowest concentration tested.

  • e NA, not applicable as QC ranges that included at least 95% of the observed values could not be set.