TABLE 2

TB-LAMP performance against two routine smears, one solid culture and one liquid culture, and species identification where appropriatea

ParameteraPoint estimate (%) (95% CI), sample size by location
IndiaUgandaPeruAll sites
Overall sensitivity (C+)88.2 (80.4–93.8), 10276.6 (69.8–82.5), 18494.3 (88.1–97.9), 10684.4 (80.5–87.9), 392
S+C+97.3 (90.5–99.7), 7395.5 (89.7–98.5), 110100.0 (94.6–100), 6797.2 (94.3–98.9), 250
S−C+65.5 (45.7–82.1), 2948.6 (36.9–60.6), 7484.6 (69.5–94.1), 3962.0 (53.5–70.0), 142
HIV− or unknown88.1 (80.2–93.7), 10178.0 (69.7–84.8), 12794.2 (87.9–97.9), 10486.1 (82.0–89.7), 332
HIV+100 (2.5–100), 173.7 (60.3–84.5), 57100 (15.8–100), 275.0 (62.1–85.3), 60
Overall specificity (S−C−)94.5 (92–96.4), 47297.5 (95.8–98.7), 52498.0 (96–99.2), 35796.6 (95.5–97.5), 1,353
  • a C+, culture positive; C−, culture negative; S+, smear positive; S−, smear negative; HIV+, HIV positive; HIV−, HIV negative.