TABLE 3

In vitro susceptibility of 172 isolates of C. guilliermondii and C. fermentati to nine antifungal agents as interpreted by breakpoints for three echinocandins and epidemiological cutoff values for other agents

C. guilliermondii complex (no. of isolates)MIC(mg/liter)No. (%) of isolates by ECVsaNo. (%) of isolates by BPsb
RangeMIC50MIC90WTnon-WTSIR
C. guilliermondii (164)
    Fluconazole1–>256216146 (89.0)18 (11.0)
    Itraconazole0.06–>160.120.5159 (96.9)5 (3.1)
    Voriconazole0.015–>80.060.25148 (90.2)16 (9.8)
    Posaconazole0.015–>80.125157 (95.7)7 (4.3)
    5-Flucytosine≤0.06–>640.060.06154 (93.9)10 (6.1)
    Caspofungin0.06–>80.251163 (99.4)0 (0)1 (0.6)
    Micafungin0.06–>80.251161 (98.2)1 (0.6)2 (1.2)
    Anidulafungin0.06–>812159 (97.0)2 (1.2)3 (1.8)
    Amphotericin B0.12–10.250.5164 (100)0 (0)
C. fermentati (8)
    Fluconazole1–48 (100)0 (0)
    Itraconazole0.06–0.58 (100)0 (0)
    Voriconazole0.015–0.128 (100)0 (0)
    Posaconazole0.015–0.258 (100)0 (0)
    5-Flucytosine≤0.068 (100)0 (0)
    Caspofungin0.03–0.58 (100)0 (0)0 (0)
    Micafungin0.03–0.58 (100)0 (0)0 (0)
    Anidulafungin0.03–28 (100)0 (0)0 (0)
    Amphotericin B0.12–0.58 (100)0 (0)
  • a Epidemiological cutoff values (ECVs) were referred to CLSI M59 (11).

  • b Breakpoints (BPs) were referred to CLSI M27 (12).