TABLE 1.

Estimation of the nucleotide substitution rate in the VP1 capsid region of CVA16

Data setSubstitution rate (substitutions per nucleotide per yr)a
KsR2KtR2
Cluster B1ab1.25 × 10−20.7563.75 × 10−30.600
Subgenotype B2c1.19 × 10−20.9733.41 × 10−30.976
Avgd0.91 × 10−22.49 × 10−3
  • a Ks, synonymous substitutions; Kt, total substitutions; R2, linear regression coefficient.

  • b Twenty-six strains, 1997-2008.

  • c Nine strains, 1981-2000.

  • d Average for cluster B1a and subgenotype B2.