TABLE 4.

PK and PD data in relation to wild-type MIC distributionsa

Wild-type MIC (mg/liter)AmikacinbKanamycincCapreomycindViomycineStreptomycinf
fCmax/MICnfCmax/MICnfCmax/MICnfCmax/MICnfCmax/MICn
0.12517301580160016001802
0.2508627908008009020
0.543334044004044547
1.0 22 532016202720452310
2.0*11010601059 10 39 11 5
4.050 5 8 5 25060
8.03020303030
  • a Values in bold represent the Cmax/MIC level for the ECOFF. The asterisk represents the lowest MIC level with a PD target of at least 10 for the Cmax/MIC, which is generally accepted for aminoglycosides (3, 18, 19).

  • b Normal dosage, 1 g/day; protein binding, 10%; fCmax, 21.6.

  • c Normal dosage, 1 g/day; protein binding, 10%; fCmax, 19.8.

  • d Normal dosagge, 1 g/day; protein binding, 20%; fCmax, 20.0.

  • e Normal dosage, 1 g/day; protein binding, 20%; fCmax, 20.0.

  • f Normal dosage, 1 g/day; proteing binding, 10%; fCmax, 22.5.