TABLE 3.

Clinical characteristics of patients suspected of enterovirus infection according to the presence of the enterovirus genome by real-time RT-PCR

CharacteristicaValue for patients:P
Negative by PCR (n = 272)Positive by PCR (n = 447)
Age (mo) (mean ± SD)†48.8 ± 93.334.5 ± 35.90.06
Male gender152 (55.9)265 (59.3)0.37
Time interval (days) (mean ± SD)†2.7 ± 4.52.6 ± 3.80.71
Clinical category
    HFMD152 (55.9)261 (58.4)0.51
    Herpangina125 (46.0)194 (43.4)0.50
    Meningoencephalitis11 (4.0)67 (15.0)<0.01
Presenting symptoms
    Fever (>37°C)93 (35.7)143 (32.0)0.31
    Headache20 (7.4)44 (9.8)0.26
    Vomiting23 (8.5)48 (10.7)0.32
    Neck stiffness*3 (1.1)13 (2.9)0.05
    Sore throat47 (17.3)82 (18.3)0.72
    Abdominal pain*6 (2.2)7 (1.6)0.53
    Diarrhea13 (4.8)11 (2.5)0.09
    Decreased mental status*1 (0.4)12 (2.7)0.02
    Seizure7 (2.6)13 (2.9)0.79
  • a Except where otherwise indicated, values are the number (percentage) of patients with the characteristic. Symbols indicate that either the Fisher exact test (*) or the Student t test (†) was used to determine significance.