TABLE 8.

Clinical sensitivities and specificities of three assaysa for N. gonorrhoeae

Specimen typeb and symptom status% sensitivity (range) % specificity (range)
ABT m2000GP AC2BD ProbeTecABT m2000GP AC2BD ProbeTec
Endocervical
    Symptomatic87.1 (70.2-96.4)90.6 (75.0-98.0)87.5 (71.0-96.5)99.7 (99.0-100.0)99.4 (98.6-99.8)99.6 (98.8-99.9)
    Asymptomatic91.3 (72.0-98.9)90.9 (70.8-98.9)91.3 (72.0-98.9)100.0 (99.5-100.0)99.7 (99.0-100.0)98.9 (97.8-99.6)
CC vaginal
    Symptomatic96.8 (83.3-99.9)93.8 (79.2-99.2)NAc 99.9 (99.2-100.0)99.3 (98.4-99.8)NA
    Asymptomatic95.7 (78.1-99.9)95.7 (78.1-99.9)NA99.4 (98.5-99.8)99.7 (98.9-100.0)NA
SC vaginal
    Symptomatic96.7 (82.8-99.9)NANA99.7 (98.9-100.0)NANA
    Asymptomatic95.7 (78.1-99.9)NANA100.0 (99.4-100.0)NANA
Female urine
    Symptomatic93.8 (79.2-99.2)84.4 (67.2-94.7)76.7 (57.7-90.1)99.7 (99.0-100.0)99.6 (98.8-99.9)95.6 (93.7-97.0)
    Asymptomatic87.0 (66.4-97.2)82.6 (61.2-95.0)85.7 (63.7-97.0)99.6 (98.7-99.9)99.4 (98.5-99.8)96.9 (95.3-98.1)
Urethral
    Symptomatic99.2 (97.0-99.9)99.2 (97.0-99.9)NA99.3 (98.3-99.8)99.2 (98.1-99.7)NA
    Asymptomatic81.8 (48.2-99.7)81.8 (48.2-97.7)NA99.8 (99.1-100.0)99.7 (98.9-100.0)NA
Male urine
    Symptomatic98.8 (96.4-99.7)97.9 (95.2-99.3)94.9 (91.3-97.3)99.5 (98.5-99.9)99.7 (98.8-100.0)97.0 (95.2-98.2)
    Asymptomatic100.0 (71.5-100.0)100.0 (71.5-100.0)100.0 (69.2-100.0)100.0 (99.4-100.0)99.5 (98.7-99.9)95.7 (93.8-97.2)
All types
    Symptomatic97.8 (96.3-98.8)97.1 (95.3-98.3)92.3 (88.6-95.0)99.6 (99.4-99.8)99.4 (99.1-99.7)97.5 (96.7-98.1)
    Asymptomatic92.1 (85.5-96.3)90.0 (81.9-95.3)90.7 (79.7-96.9)99.8 (99.6-99.9)99.6 (99.3-99.8)97.2 (96.4-97.9)
Overall96.9 (95.4-98.1)96.1 (94.3-97.4)92.0 (88.7-94.6)99.7 (99.6-99.8)99.5 (99.3-99.7)97.3 (96.8-97.8)
  • a GP AC2, GenProbe Aptima Combo 2; BD ProbeTec, Becton Dickinson ProbeTec; ABT m2000, Abbott m2000.

  • b CC, clinician collected; SC, self-collected.

  • c NA, not applicable.