TABLE 5.

Viral titers from nasal excretions of tested H1N1 viruses in infected and contact ferretsa

DayViral titersb (SD) for:
Korea/CJ01/09Sw/Korea/SCJ01/09Sw/Korea/CAN01/04
InoculatedContactInoculatedContact 1Contact 2InoculatedContact 1Contact 2
0
15.38 (0.5)5.25 (0.3)4.50 (0.4)
26.50 (0.4)c6.63 (0.3)c2.255.38 (0.3)c
34.75 (0.3)2.25 (0.4)5.00 (0.4)4.251.55.13 (0.5)2.25
43.50 (0.5)4.25 (0.4)3.67 (0.3)3.253.753.50 (0.0)1.75
52.17 (0.3)3.50 (0.5)2.33 (0.3)2.753.252.17 (0.3)1.25
61.50 (0.7)2.25 (0.4)1.75 (0.4)1.52.751.25 (0.4)
71.25 (0.4)1.25
8
9
  • a Groups of ferrets were inoculated i.n. with 105 TCID50 of respective viruses in 1 ml of sterile PBS under isoflurane anesthesia. Animals were infected in an enhanced biosafety level 3 (ABSL-3+) containment facility. Virus titrations were done in 11-day-old embryonated chicken eggs calculated by the method of Reed and Muench (32) and expressed as log10 EID50/ml. Dashes indicate no detectable titers.

  • b Mean viral titers from nasal washes.

  • c P < 0.05; compared peak virus titers of ferrets infected with the pandemic viruses (Korea/CJ01/09 and Sw/Korea/SCJ01/09) relative to Sw/Korea/CAN01/04-infected ferrets.