TABLE 7.

Clinical sensitivities and specificities of three assaysa for C. trachomatis

Specimen typeb and symptom status% sensitivity (range) % specificity (range)
ABT m2000GP AC2BD ProbeTecABT m2000GP AC2BD ProbeTec
Endocervical
    Symptomatic87.7 (78.5-93.9)91.4 (83.0-96.5)88.8 (79.7-94.7)99.7 (98.9-100.0)99.4 (98.5-99.8)99.1 (98.0-99.7)
    Asymptomatic80.9 (66.7-90.9)78.7 (64.3-89.3)78.3 (63.6-89.1)99.4 (98.4-99.8)98.6 (97.4-99.4)99.8 (99.1-100.0)
CC vaginal
    Symptomatic92.5 (84.4-97.2)92.6 (84.6-97.2)NAc 98.8 (97.6-99.5)98.7 (97.5-99.4)NA
    Asymptomatic87.2 (74.3-95.2)85.1 (71.7-93.8)NA99.1 (98.0-99.7)98.2 (96.8-99.1)NA
SC vaginal
    Symptomatic94.7 (86.9-98.5)NANA99.0 (97.9-99.6)NANA
    Asymptomatic84.8 (71.1-73.7)NANA98.9 (97.7-99.6)NANA
Female urine
    Symptomatic92.6 (84.6-97.2)93.8 (86.2-98.0)90.9 (82.2-96.3)99.5 (98.7-99.9)99.4 (98.5-99.8)99.7 (98.8-100.0)
    Asymptomatic95.7 (85.2-99.5)93.5 (82.1-98.6)91.3 (79.2-97.6)99.2 (98.2-99.7)99.2 (98.2-99.8)99.7 (98.8-100.0)
Urethral
    Symptomatic93.3 (86.6-96.5)98.4 (95.3-99.7)NA98.3 (97.0-99.1)98.5 (97.2-99.3)NA
    Asymptomatic88.6 (80.1-94.4)91.2 (83.4-96.1)NA99.1 (97.9-99.7)99.1 (98.0-99.7)NA
Male urine
    Symptomatic97.3 (93.7-99.1)99.5 (97.0-100.0)91.0 (85.7-94.7)99.7 (98.9-100.0)99.4 (98.4-99.8)99.0 (97.9-99.6)
    Asymptomatic97.8 (92.3-99.7)98.9 (94.0-100.0)95.5 (88.9-98.8)99.6 (98.7-100.0)99.5 (98.5-99.9)99.4 (98.4-99.9)
All types
    Symptomatic93.7 (91.6-95.4)96.4 (94.5-97.7)90.4 (86.7-93.4)99.2 (98.8-99.4)99.1 (98.7-99.4)99.3 (98.8-99.6)
    Asymptomatic90.1 (86.6-93.0)91.0 (87.3-93.9)90.1 (84.7-94.0)99.2 (98.9-99.5)98.9 (98.5-99.2)99.7 (99.3-99.9)
Overall92.4 (90.7-94.0)94.5 (92.9-95.9)90.3 (87.4-92.7)99.2 (99.0-99.4)99.0 (98.7-99.2)99.5 (99.2-99.7)
  • a GP AC2, GenProbe Aptima Combo 2; BD ProbeTec, Becton Dickinson ProbeTec; ABT m2000, Abbott m2000.

  • b CC, clinician collected; SC, self-collected.

  • c NA, not applicable.