Characteristics of patients and febrile episodes

Febrile neutropenic patient characteristic (n = 86)Valuea
    Male/female53 (62)/33 (38)
    Median age in yr (range)54 (17-71)
Hematological malignancies
    Acute myeloid leukemia/acute
        lymphoblastic leukemia37 (43)/9 (10)
    Lymphoma12 (14)
    Multiple myeloma22 (26)
    Other6 (7)
    Induction/consolidation for acute leukemia45 (52)
    Autologous HSCTb37 (43)
    Other4 (5)
Median no. of days of neutropenia (range)11 (1-140)
Febrile episodes (n = 141)
    First febrile episodes85 (60)
    Recurrent febrile episodes56 (40)
    Ongoing antimicrobial therapy at
        onset of fever51 (36)
Microbiologically documented infections
        (MDI)44 (31)
    Bacteremic35 (25)
        Single Gram-positive bacterial species13 (37)
        Single Gram-negative bacterial species15 (43)
        Polymicrobial7 (20)
    Nonbacteremicc9 (6)
Clinically documented infection (CDI)49 (35)
    Upper/lower gastrointestinal tract36 (73)
    Upper/lower airways6 (12)
    Catheter/skin/soft tissues7 (14)
Fever of unexplained origin (FUO)48 (34)
Episodes with persistent fever for ≥3 days52 (36)
Invasive fungal infections
        (EORTC-MSG criteria)7 (5)
  • a Values represent number (percent) except where otherwise indicated.

  • b HSCT, hematopoietic stem cell transplantation.

  • c Four cases of enterocolitis (Clostridium difficile infection), one of pneumonia (Pneumocystis jiroveci), and four of urinary tract infections (two Escherichia coli, one Enterobacter cloacae, and one Klebsiella pneumoniae). Clostridium difficile and Pneumocystis jiroveci are not in the SF analytical spectrum. In one of the four urinary tract infections, SF detected the same microorganism (K. pneumoniae/K. oxytoca) in blood.