TABLE 1.

Details of C. diphtheriae strains useda

Strain identificationeBURST groupPrevious designationReferral laboratorySequence typeAllelic profileYr isolatedCountry/state/city of isolationDiseaseSite of isolationBiotypeDT status
271(MS) 7/97NIPH323-1-18-4-13-3-51997PolandNKNKGNK
641CD293CDC323-1-18-4-13-3-51996KazakhstanNKNKM+
661CD295CDC323-1-18-4-13-3-51996KazakhstanNKThroatM
781CD373CDC363-7-18-4-13-3-52005USA, CaliforniaSore throatThroatG
961722CDC4315-1-18-4-13-3-51986Russia, KovrovCarrierThroatG+
1271CD286CDC583-1-26-4-13-3-51996KazakhstanNKNKG+
1291CD303CDC703-1-18-4-20-3-51997USA, MichiganNKBloodG
8295-135HPA83-5-6-5-3-3-61993FinlandNKNKG+
252493/K/04NIPH83-5-6-5-3-3-62004PolandNKNKG-
362G4174CDC83-5-6-5-3-3-61993Russia, LeningradDiphtheriaNKG+
452CD126CDC83-5-6-5-3-3-61985Russia, MoscowDiphtheriaNKG+
462CD130CDC83-5-6-5-3-3-61987Russia, SverdlovskTonsillitisNKG+
472CD131CDC83-5-6-5-3-3-61987Russia, SverdlovskCarrierNKG+
622CD290CDC83-5-6-5-3-3-61996KazakhstanNKNKG+
632CD291CDC83-5-6-5-3-3-61996KazakhstanNKNKG+
652CD294CDC83-5-6-5-3-3-61996KazakhstanNKNoseM-
1262CD283CDC83-5-6-5-3-3-61996KazakhstanNKNKG+
13293-146HPA121-5-6-5-3-3-61993Russia, KaliningradCarrierNKG+
1242CD267CDC523-5-6-5-3-10-61996KazakhstanNKNKG+
693CD306CDC426-7-10-8-9-12-101997USA, MichiganNKSputumB-
952749CDC663-5-6-5-11-3-61987Russia, KovrovNKThroatG+
1163CD198CDC516-7-10-8-9-19-101999USA, CaliforniaNKNoseB-
1333CD310CDC546-7-10-22-9-12-101998USA, OhioNKSputumB-
10493-32HPA105-2-7-1-3-5-81993UKNKNKG+
1084CD170CDC492-6-7-1-3-5-81973South DakotaNKNKG+
1154CD196CDC635-6-7-1-3-5-81978USA, ColoradoNKThroatG+
19595-115HPA188-6-7-6-6-3-81995Russia, Vladimir regionDiphtheriaNKG+
20593-181HPA192-6-7-6-6-3-81966Russia, MoscowCarrierNKG+
12593-69HPA255-6-7-6-6-3-8NKRussia, MurmanskDiphtheriaNKG+
395CD085CDC255-6-7-6-6-3-81957Russia, VladivostokDiphtheriaNKG+
405CD087CDC255-6-7-6-6-3-81957Russia, VladivostokCarrierNKG+
415CD092CDC255-6-7-6-6-3-81964Russia, MoscowCarrierNKG+
425CD094CDC255-6-7-6-6-3-81965Russia, MoscowCarrierNKG+
435CD097CDC255-6-7-6-6-3-81971Russia, MoscowCarrierNKG+
515PR79CDC255-6-7-6-6-3-81996USA, South DakotaNKNKG+
1255CD268CDC255-6-7-6-6-3-81996KazakhstanNKNKG+
976G4212CDC452-10-24-1-3-15-21992Russia, MurmanskDiphtheriaNKM+
1286CD301CDC532-10-24-1-3-3-21997USA, OregonNKThroatM-
5271507CDC282-9-3-13-3-3-31995KyrgyzstanNKNKM+
5371512CDC412-9-22-13-3-3-31995KyrgyzstanNKNKM+
21890-39HPA208-3-3-2-7-3-31990UK, LondonTonsillitisNKM+
678CD304CDC408-3-19-2-7-3-31997GuatemalaNKNKM-
1038CD081CDC408-3-19-2-7-3-31997Russia, MoscowNKNKM-
1188CD209CDC408-3-19-2-7-3-31997RussiaNKNKM-
4995-385HPA43-2-4-3-4-4-41995Dominican RepublicNKNKM+
1589CD333CDC43-2-4-3-4-4-42004Dominican RepublicNKNKM+
599CD216CDC313-2-4-15-4-4-42000Dominican RepublicNKNKM+
749CD340CDC313-2-4-15-4-4-42004HaitiDiphtheriaThroatM+
1499CD324CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1509CD325CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1519CD326CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1529CD327CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1539CD328CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1559CD330CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1569CD331CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1579CD332CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1599CD334CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1619CD336CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1629CD337CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1649CD339CDC313-2-4-15-4-4-42004Dominican RepublicNKNKM+
1679CD342CDC313-2-4-15-4-4-42004HaitiDiphtheriaNKM+
1699CD344CDC313-2-4-15-4-4-42004HaitiNKNoseM+
1709CD345CDC313-2-4-15-4-4-42004HaitiDiphtheriaNKM+
1719CD346CDC313-2-4-15-4-4-42004HaitiDiphtheriaNKM+
1729CD347CDC313-2-4-15-4-4-42004HaitiDiphtheriaNKM+
1739CD350CDC313-2-4-15-4-4-42004HaitiNKThroatM+
1749CD352CDC313-2-4-15-4-4-42004HaitiDiphtheriaNKM+
1769CD354CDC313-2-4-15-4-4-42005HaitiDiphtheriaNKM+
1779CD359CDC313-2-4-15-4-4-42005HaitiDiphtheriaNKM+
1789CD360CDC313-2-4-15-4-4-42005HaitiDiphtheriaNKM+
1799CD371CDC313-2-4-15-4-4-42005HaitiDiphtheriaNKM+
1819CD400CDC313-2-4-15-4-4-42006HaitiDiphtheriaNKM+
5510CD204CDC2910-8-16-14-10-3-51990Russia, SelivavovoNKThroatM
5710CD211CDC3010-8-16-14-10-3-91997RussiaNKNKM
10210CD080CDC3010-8-16-14-10-3-91997Russia, MoscowNKNKM
10410CD082CDC3010-8-16-14-10-3-91997Russia, MoscowNKNKM
11710CD208CDC3010-8-16-14-10-3-91997RussiaNKNKM
51193-186HPA52-4-4-1-3-3-51989Russia, St. PetersburgCarrierNKM
221193-218HPA52-4-4-1-3-3-51993Russia, St. PetersburgCarrierNKM
5611CD207CDC52-4-4-1-3-3-51997RussiaNKNKM
6811CD305CDC52-4-4-1-3-3-51997USA, MassachusettsNKSputumM
91193-266HPA92-4-4-1-3-3-71993Russia, St. PetersburgDiphtheriaNKG+
194-94HPA11-1-1-1-1-1-1NKSwedenNKNKM+
113CD187CDC11-1-1-1-1-1-11984-1986SwedenNKNKM+
294-249HPA22-2-2-1-2-2-2NKRomaniaNKNKM
385-29HPA33-3-3-2-3-3-31985UK, SwanseaNKNKM+
2393-211HPA33-3-3-2-3-3-31993UKNKNKM+
693-154HPA64-2-5-2-3-3-51993UKNKNKM+
794-282HPA72-5-6-4-5-5-21994ItalyPharyngitisNKM
1195-387HPA113-4-3-1-4-3-21995Dominican RepublicNKNKM+
1494-263HPA136-4-8-1-7-3-91994ThailandSkin lesionNKM+
1592-48HPA143-2-9-7-8-3-21992UK, BristolNKNKM+
1694-260HPA157-7-10-8-9-6-101993GermanyNKNKB
1793-121HPA165-8-11-9-3-3-51993UKNKNKM+
1893-132HPA175-8-12-10-10-6-41993Russia, KaliningradCarrierNKM+
2485-2HPA219-4-13-11-3-3-91985UK, SwanseaTonsillitisNKM+
34CD027CDC222-2-14-4-11-3-41958Canada, TorontoUlcerNKM+
35C78CDC236-7-10-12-16-7-111986Canada, E. OntarioNKThroatB
37711CDC242-4-15-6-7-8-91985Russia, VladimirNKThroatM+
38G4182CDC242-4-15-6-7-8-91992Russia, VladimirNKThroatM+
44CD113CDC242-4-15-6-7-8-91976Russia, IvanobsayaTonsillitisNKM+
54CD203CDC242-4-15-6-7-8-91990Russia, VladimirNKThroatM
48C75CDC268-2-16-1-3-3-121996Canada, James BayNKThroatB+
193CD149CDC268-2-16-1-3-3-121998Canada, James BayNKThroatB
194CD150CDC268-2-16-1-3-3-121998Canada, James BayNKThroatB+
195CD162CDC268-2-16-1-3-3-121995Canada, James BayNKEarB+
196CD163CDC268-2-16-1-3-3-121995Canada, James BayNKThroatB+
49CD164CDC272-4-17-4-7-5-41995ArgentinaDiphtheriaNKM+
70CD314CDC3311-1-20-16-3-9-141998USA, MassachusettsNKBloodG
71CD315CDC3311-1-20-16-3-9-141998USA, MassachusettsNKBloodG
72CD317CDC3412-7-10-17-9-7-101999USA, MaineNKSputumB
76CD372CDC356-7-21-12-15-7-112005USA, PennsylvaniaNKBronchialB
79CD376CDC376-7-10-18-9-13-22006USA, ColoradoNKSputumB
61CD222CDC382-10-29-1-12-10-131971USA, ArizonaNKNKI
107CD169CDC382-10-29-1-12-10-131979USA, South DakotaNKThroatI+
120CD230CDC382-10-29-1-12-10-131971USA, WashingtonNKNKI
122CD233CDC382-10-29-1-12-10-131971USA, WashingtonNKNKI
123CD235CDC382-10-29-1-12-10-131971USA, WashingtonNKNKI
73CD318CDC3913-1-8-4-14-11-21999USA, MaineNKSputumG
80CD383CDC3913-1-8-4-14-11-21996USA, CaliforniaNKNKG
131CD308CDC3913-1-8-4-14-11-21998USA, CaliforniaNKBloodG
137CD322CDC3913-1-8-4-14-11-21999USA, CaliforniaNKSynovialG
138CD323CDC3913-1-8-4-14-11-21999USA, CaliforniaNKBloodG
29(MZ) 113/GNIPH4414-2-23-4-2-14-21990sPolandSkin ulcerThroatM+
30(MZ) 115/SNIPH4414-2-23-4-2-14-21990sPolandSkin ulcerSkinM+
31(MM) 4/GNIPH4414-2-23-4-2-14-21990sPolandNKThroatI+
32(AW) 6/GNIPH4414-2-23-4-2-14-21990sPolandNKThroatM+
98724CDC4616-4-8-1-7-16-91987Russia, VladimirNKNKM+
99760CDC472-11-9-19-17-17-91989Russia, KovrovNKThroatM
1001709CDC484-4-25-6-3-5-91988Russia, PenzaNKThroatM+
109CD177CDC502-2-4-1-3-3-21981South DakotaNKNKM
110CD178CDC502-2-4-1-3-3-21981South DakotaNKNKM
111CD179CDC502-2-4-1-3-3-21982South DakotaNKNKM
139CD364CDC552-13-28-4-4-4-42004USA, New YorkNKBloodM
112CD186CDC5619-12-11-9-18-18-21984SwedenNKNKG+
114CD188CDC5717-10-30-23-20-3-161985SwedenNKNKG+
130*CD307CDC5918-1-27-21-20-5-161998USA, VirginiaChest woundThoracic exudateG+
132*CD309CDC5918-1-27-21-20-5-161998USA, VirginiaNKPlacentaG
101750CDC602-5-3-1-3-3-91988Russia, KovrovNKNKM+
106CD167CDC613-4-8-1-7-3-41973South DakotaNKNKM
105CD089CDC624-1-18-4-3-16-21957Russia, VladivostokCarrierNKG
140CD365CDC642-10-17-13-3-2-42005USA, New YorkNKAnkleM
261034NIPH656-7-10-12-9-12-152001PolandNKNoseBNK
75CD349CDC673-2-3-6-3-3-22004USA, MassachusettsCarrierThroatM+
154CD329CDC673-2-3-6-3-3-22004Dominican RepublicNKNKM+
166CD341CDC683-4-3-4-4-3-42004HaitiSkin lesionNKM+
28(PJ)891/N/00NIPH696-7-21-17-9-7-112000PolandNKNoseB
183CD402CDC7121-7-21-12-21-12-112006USA, MinnesotaNKNasal dischargeB
18653NCLD722-8-4-1-3-4-2NKAngolaOsteomyelitis, cutaneousThighM+
18552NCLD732-8-9-27-18-3-18NKAngolaOsteomyelitis, cutaneousFootM+
  • a ”NK” is used where clinical data are not known. Toxigenicity information is provided by “+” for toxin positive and “−” for toxin negative under the diphtheria toxin status (DT) column. Biotypes are indicated as follows: B, biotype belfanti; I, intermedius; G, gravis; and M, mitis. All isolates were cultured from humans with the exception of those highlighted by an asterisk (*), which were obtained from horses. Strains were obtained from the Health Protection Agency (HPA), Centers for Disease Control (CDC), the National Consiliary Laboratory for Diphtheria (NCLD), and the National Institute of Public Health (NIPH).