Table 1.

IC50 and IC90 of ganciclovir-sensitive (AD169) and -resistant (D6/3/1) strains of HCMV

VirusGCVa concn (μM)% IE Ag+b cells% Late Ag+cellsIC50 (μM)IC90 (μM)
AD169098.940.8
1.596.219.11.7
3.093.414.5
12.096.42.29.2
D6/3/1097.341.6
1.597.038.8
3.096.238.8
12.097.441.7>12>12
  • a GCV, ganciclovir.

  • b IE Ag+, immediate-early antigen-positive.