TABLE 2.

Antifungal activities of fluconazole, itraconazole, and investigational azole antifungal agents against 2,029 invasive isolates of Candida spp. by patient age group, SENTRY Program, 1997 to 2000

Species (no. of isolates) and anti- fungal agent<1 yr2-15 yr16-64 yr>65 yr
No. of isolatesMIC50/MIC90 (μg/ml)% Sus- ceptibleaNo. of isolatesMIC50/MIC90 (μg/ml)% Sus- ceptibleNo. of isolatesMIC50/MIC90 (μg/ml)% Sus- ceptibleNo. of isolatesMIC50/MIC90 (μg/ml)% Sus- ceptible
C. albicans (1,114)
    Fluconazole1630.25/0.5100680.25/0.5995690.25/0.5983140.25/0.599
    Itraconazole1630.03/0.1295680.03/0.12975690.03/0.12953140.03/0.1297
    Posaconazole1630.03/0.06100680.03/0.06985690.03/0.06993140.03/0.0699
    Ravuconazole1630.01/0.03100680.01/0.03985690.01/0.03993140.01/0.0399
    Voriconazole1630.01/0.03100680.01/0.03995690.01/0.03993140.01/0.0398
C. glabrata (334)
    Fluconazole88/—b6342/—751808/32701428/1673
    Itraconazole81/—1340.25/—1001800.5/281420.5/26
    Posaconazole80.25/—10040.25/—1001800.5/2881420.5/197
    Ravuconazole80.12/—10040.12/—1001800.25/2891420.25/0.597
    Voriconazole80.5/—10040.06/—1001800.12/1901420.12/195
C. parapsilosis (301)
    Fluconazole660.5/2100270.5/41001250.5/2100830.5/2100
    Itraconazole660.12/0.2580270.12/0.25631250.12/0.2564830.12/0.2563
    Posaconazole660.03/0.12100270.06/0.121001250.06/0.12100830.06/0.12100
    Ravuconazole660.03/0.06100270.03/0.061001250.03/0.06100830.03/0.06100
    Voriconazole660.03/0.06100270.03/0.061001250.03/0.06100830.03/0.12100
C. tropicalis (209)
    Fluconazole200.5/1100130.5/21001130.5/296630.5/1100
    Itraconazole200.12/0.2570130.12/0.5621130.12/0.568630.12/0.2567
    Posaconazole200.03/0.12100130.03/0.121001130.03/0.1299630.03/0.25100
    Ravuconazole200.03/0.06100130.03/0.121001130.03/0.1297630.03/0.12100
    Voriconazole200.06/0.12100130.03/0.061001130.03/0.1297630.03/0.12100
C. krusei (39)
    Fluconazole516/—202332/6491132/649
    Itraconazole50.25/—40230.5/20111/29
    Posaconazole50.5/—100230.25/0.5100110.25/0.5100
    Ravuconazole50.25/—100230.25/0.595110.5/0.5100
    Voriconazole50.12/—100230.25/1100110.5/1100
C. guilliermondii (14)
    Fluconazole62/—10022/—10052/—1001>640
    Itraconazole60.25/—020.12/—5050.25/—401>40
    Posaconazole60.12/—10020.06/—10050.06/—1001>80
    Ravuconazole60.25/—7520.03/—10050.06/—100>80
    Voriconazole60.06/—10020.03/—10050.06/—1001>80
C. lusitaniae (18)
    Fluconazole70.25/—10020.25/—10060.25/—10030.5/—67
    Itraconazole70.12/—7120.06/—5060.12/—5030.25/—33
    Posaconazole70.03/—10020.03/—10060.03/—10030.03/—100
    Ravuconazole70.03/—10020.03/—10060.03/—10030.03/—67
    Voriconazole70.03/—10020.01/—10060.01/—10030.01/—100
  • a Percent susceptible at MIC of ≤8 μg/ml (fluconazole), ≤0.12 μg/ml (itraconazole), or ≤1 μg/ml (all other agents).

  • b —, MIC90 was not calculated when the number of isolates tested was <10.