TABLE 4

Identification and characterization of specific genes of samples SWEH1 to SWEH7 with variants causing nonsynonymous substitutions

GeneDescriptionGene Ontology classificationAmino acid changePROVEAN scoreSIFT result
cgd6_140Possible Na+/H+ and K+/H+ antiporterpH, solute:hydrogen antiporter activityV687I0.17
cgd6_200Oocyst wall protein 8 H205–H206insGH0.70
cgd6_210Oocyst wall protein 9 L818del1.75b0b
cgd6_210Oocyst wall protein 9 T817P1.220b
cgd7_90High-affinity sulfate transporter relatedActive sulfate transmembrane transporterS539F0.37
cgd7_1730CpCCp1/Cpa135 A1473T0.03
cgd7_1800Oocyst wall protein 2Chitin metabolic process, chitin bindingT570K0.21
cgd7_4080Protein disulfide isomerase, Signal peptide, ERa retention motifProtein folding and disulfide isomerase activityG292S0.65
cgd3_3520Putative sodium/calcium cation exchangerTransmembrane transportV6 M0.05
cgd8_30Signal peptide, cryptosporidium-specific SKSR gene family V203A0.71
cgd8_50Signal peptide, cryptosporidium-specific FGLN gene family N387S0.17
cgd8_50Signal peptide, cryptosporidium-specific FGLN gene family V259I0.08
cgd5_3420TRAP-C2 extracellular proteinCell differentiationN1567S0.35
cgd5_3420TRAP-C2 extracellular proteinCell differentiationE2471del0.54
cgd4_1080Conserved hypothetical proteinCell redox homeostasis, catalyticM146I0.04
cgd6_3640Protein disulfide isomeraseCell redox homeostasis, isomerase activityN201T0.06
cgd6_4450Possible apicomplexan-specific small proteinProtein transport, metal ion bindingS80R3.48b0b
cgd8_3910Na-dependent inorganic phosphate cotransporterTransmembrane transportI288V0.08
  • a ER, endoplasmic reticulum.

  • b Predicted deleterious mutation.