TABLE 2

Comparison of sensitivities, specificities, likelihood ratios, and predictive values determined by ID and the MVista anti-Coccidioides antibody EIA at different cutoff values and estimates of prevalence

Test and cutoff valueSensitivity (%)Specificity (%)LR+aLR−Prevalence of 5%Prevalence of 10%
PPVNPVPPVNPV
EIA, IgG
    10 EU87.490.08.740.1431.599.349.398.5
    20 EU60.299.4100.30.4084.197.991.895.7
EIA, IgM
    10 EU61.295.313.00.4140.797.959.195.7
    20 EU30.199.450.20.7072.596.484.892.8
EIA, IgG or IgM
    10 EU88.390.08.830.1331.799.349.598.6
    20 EU60.299.4100.30.4084.197.991.895.7
IDCF53.398.844.50.4770.097.683.195.0
IDTP33.01000.6710096.610093.1
IDCF or IDTP60.198.850.10.4072.597.984.895.7
  • a LR+, positive likelihood ratio; LR−, negative likelihood ratio; PPV, positive predictive value; NPV, negative predictive value; IDCF, immunodiffusion with the CF antigen; IDTP, immunodiffusion with the TP antigen; ∞, perfect specificity results with an infinite positive likelihood ratio.