TABLE 3

Analysis of parameters potentially affecting the sensitivity of anti-Coccidioides antibody detection

Clinical factor and immunoglobulinSensitivity (%)P
MVista EIAIDa
Pulmonary disease (n = 72)
    IgG90.245.8<0.0001
    IgM66.734.7<0.0001
    IgG or IgM90.254.2<0.0001
Disseminated disease (n = 31)
    IgG80.671.00.289
    IgM48.425.80.016
    IgG or IgM83.971.00.180
Immunocompromised (n = 30)
    IgG83.340.00.002
    IgM56.730.00.022
    IgG or IgM83.350.00.012
Immunocompetent (n = 73)
    IgG90.458.9<0.0001
    IgM63.032.9<0.0001
    IgG or IgM90.463.0<0.0001
Antifungal treated (n = 78)
    IgG87.257.7<0.0001
    IgM60.329.5<0.0001
    IgG or IgM88.562.3<0.0001
Untreated (n = 25)
    IgG88.040.00.005
    IgM64.040.00.109
    IgG or IgM88.052.00.004
  • a IgG and IgM results refer to ID with the CF antigen and ID with the TP antigen, respectively.