Table 2.

MICs of voriconazole, fluconazole, itraconazole, and amphotericin B against quality control and reference isolates

IsolateAntifungal agentMIC range (μg/ml)
Present studyReferencea
C. parapsilosis (ATCC 22019)Voriconazole0.06–0.12NA
Fluconazole 2–42–8
Itraconazole0.12–0.250.06–0.25
Amphotericin B0.5–20.25–1.0
C. krusei (ATCC 6258)Voriconazole0.25NA
Fluconazole32–6416–64
Itraconazole0.25–0.50.12–0.5
Amphotericin B2 0.5–2
P. variotii(ATCC 22319)Voriconazole0.06–0.12NA
Itraconazole0.06–0.50.03–1
Amphotericin B0.25–0.50.25–1
  • a Established reference MIC ranges for the two NCCLS QC Candida strains (25). The MIC range for P. variotii was obtained in two previous collaborative studies by the NCCLS Subcommittee (9, 10). NA, not available.