Table 5.

Susceptibilities of 60 emerging yeast pathogens to voriconazole, fluconazole, itraconazole, and amphotericin Ba

Fungus (no. tested)Antimicrobial agentMIC range (μg/ml)MIC50 (μg/ml)
B. capitatus(5)Voriconazole0.06–0.250.12
Fluconazole16–6432
Itraconazole0.25–0.50.5
Amphotericin B1.0–21.0
Candida ciferrii(6)Voriconazole0.12–0.50.25
Fluconazole32–>6464
Itraconazole0.5–21.0
Amphotericin B1.0–21.0
Candida famata(5)Voriconazole<0.03–1.0<0.03
Fluconazole0.5–>642
Itraconazole0.06–0.50.12
Amphotericin B1.0–21.0
Candida kefyr(5)Voriconazole<0.03–0.06<0.03
Fluconazole0.5–42
Itraconazole0.06–0.250.25
Amphotericin B0.5–21.0
Candida lambica(6)Voriconazole<0.03<0.03
Fluconazole16–>6432
Itraconazole0.06–0.250.12
Amphotericin B0.06–0.250.12
Candida lipolytica(5)Voriconazole<0.03–0.250.06
Fluconazole4–328
Itraconazole0.12–1.00.25
Amphotericin B1.01.0
Candida rugosa(5)Voriconazole<0.03–0.060.06
Fluconazole4–168
Itraconazole0.06–0.50.25
Amphotericin B1.0–21.0
H. anomala(5)Voriconazole0.12–0.250.25
Fluconazole2–42
Itraconazole0.25–1.00.5
Amphotericin B0.25–1.01.0
R. rubra(5)Voriconazole0.25–44
Fluconazole0.5–>64>64
Itraconazole0.25–42
Amphotericin B0.5–1.00.5
S. cerevisiae(5)Voriconazole0.06–0.250.12
Fluconazole1–42
Itraconazole0.5–1.00.5
Amphotericin B0.5–21.0
S. salmonicolor(3)Voriconazole0.25–4ND
Fluconazole8–>64ND
Itraconazole1.0–2ND
Amphotericin B0.5–1.0ND
T. beigelii (5)Voriconazole<0.03–0.12<0.03
Fluconazole1.0–22
Itraconazole0.06–0.250.25
Amphotericin B0.5–22
  • a The MICs of voriconazole, fluconazole, and itraconazole correspond to prominent growth inhibition (approximately ≤50% of the growth control), and the MIC of amphotericin B corresponds to complete (100%) growth inhibition. ND, not determined.