Table 3.

Susceptibilities of 67 opportunistic filamentous and dimorphic fungi to voriconazole, itraconazole, and amphotericin Ba

Fungus (no. tested)Antifungal agentMIC range (μg/ml)G mean (μg/ml)
Opportunistic filamentous fungi
A. flavus(11)Voriconazole0.5–1.00.57
Itraconazole0.06–0.120.1
Amphotericin B1.0–21.07
 A. fumigatus(12)Voriconazole0.06–0.50.29
Itraconazole0.12–>160.24
Amphotericin B1.0 1.0
 Bipolarisspp.b (6)Voriconazole0.12–1.00.33
Itraconazole<0.03–0.120.06
Amphotericin B0.5–1.00.65
 F. oxysporum(6)Voriconazole4 4
Itraconazole1.0–>168
Amphotericin B2 2
 F. solani(6)Voriconazole8–1610.5
Itraconazole1.0–>168
Amphotericin B1.0–21.31
 P. boydii(6)Voriconazole0.25–0.50.33
Itraconazole0.5–1.00.76
Amphotericin B1.0–42.6
 R. arrhizus(5)Voriconazole8–>1618.37
Itraconazole0.25–1.00.43
Amphotericin B0.5–1.00.57
Dimorphic fungi
 B. dermatitidis (5)Voriconazole0.06–0.120.1
Itraconazole0.060.06
Amphotericin B0.12–0.250.14
 H. capsulatum(5)Voriconazole0.060.06
Itraconazole0.060.06
Amphotericin B0.25–0.50.42
 S. schenckii(5)Voriconazole8–>1616
Itraconazole0.25–1.00.5
Amphotericin B0.5–21.5
  • a The MICs of voriconazole and amphotericin B correspond to complete (100%) growth inhibition, and the MICs of itraconazole correspond to prominent growth inhibition (approximately ≤50% of the growth control).

  • b Species tested included Bipolaris hawaiiensis and Bipolaris spicifera.