Table 4.

Susceptibilities of 129 selected common pathogenic yeasts to voriconazole, fluconazole, itraconazole, and amphotericin B

Fungus (no. tested)Antimicrobial agentMIC range (μg/ml)MIC50 (μg/ml)MIC90 (μg/ml)
C. albicans(32)Voriconazole<0.03–40.060.5
Fluconazole0.12–>640.532
Itraconazole<0.03–1.00.060.5
Amphotericin B0.5–41.02
C. glabrata(14)Voriconazole0.06–40.54
Fluconazole4–641664
Itraconazole0.5–>161.02
Amphotericin B1.0–21.02
Candida guilliermondii(8)Voriconazole<0.03–0.060.06ND
Fluconazole0.5–82ND
Itraconazole0.12–0.50.25ND
Amphotericin B0.5–1.01.0ND
C. krusei (12)Voriconazole0.12–0.50.250.5
Fluconazole16–323216
Itraconazole0.12–1.00.51.0
Amphotericin B0.25–1.01.01.0
C. lusitaniae(17)Voriconazole<0.03–0.06<0.030.06
Fluconazole0.12–40.52
Itraconazole<0.03–0.50.120.25
Amphotericin B0.25–21.02
C. parapsilosis(18)Voriconazole<0.03–0.50.060.25
Fluconazole0.25–822
Itraconazole0.03–0.50.120.25
Amphotericin B1.0–21.01.0
C. tropicalis(16)Voriconazole<0.03–>160.060.25
Fluconazole0.25–>641.032
Itraconazole0.06–>160.50.5
Amphotericin B0.5–81.01.0
Cryptococcus neoformans(12)Voriconazole<0.03–0.250.060.12
Fluconazole2–16416
Itraconazole0.06–1.00.251.0
Amphotericin B1.0–21.01.0
  • a The MICs of voriconazole, fluconazole, and itraconazole correspond to prominent growth inhibition (approximately ≤50% of the growth control), and the MIC of amphotericin B corresponds to complete (100%) growth inhibition.